PARP1

PARP1

Identifiers Symbols PARP1; ADPRT; ADPRT 1; ADPRT1; ARTD1; PARP; PARP-1; PPOL; pADPRT-1 External IDs OMIM: 173870 MGI: 1340806 HomoloGene: 1222 ChEMBL: 3105 GeneCards: PARP1 Gene EC number 2.4.2.30

Gene Ontology
Molecular function DNA binding
NAD+ ADP-ribosyltransferase activity
protein binding
transcription factor binding
zinc ion binding
protein N-terminus binding
NAD binding
Cellular component nucleus
nuclear envelope
nucleoplasm
transcription factor complex
nucleolus
Biological process negative regulation of transcription from RNA polymerase II promoter
telomere maintenance
DNA repair
base-excision repair
double-strand break repair
transcription, DNA-dependent
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
protein ADP-ribosylation
transforming growth factor beta receptor signaling pathway
gene expression
protein autoprocessing
cellular response to insulin stimulus
regulation of growth rate
DNA damage response, detection of DNA damage
protein poly-ADP-ribosylation
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 142 11545 Ensembl ENSG00000143799 ENSMUSG00000026496 UniProt P09874 P11103 RefSeq (mRNA) NM_001618 NM_007415 RefSeq (protein) NP_001609 NP_031441 Location (UCSC) Chr 1:
226.55 – 226.6 Mb Chr 1:
180.57 – 180.6 Mb PubMed search

Poly polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly synthase 1 is an enzyme that in humans is encoded by the PARP1 gene.

Read more about PARP1:  Function, Interactions, See Also