Pancreatic Elastase

Pancreatic elastase is a form of elastase that is formed in the pancreas. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin.

The first isozyme, pancreatic elastase 1 was initially thought to be expressed in the pancreas. However it was later discovered that it was the only chymotrypsin-like elastase that was not expressed in the pancreas. Hence this protein has been renamed elastase 1 (ELA1) or chymotrypsin-like elastase family, member 1 (CELA1). For a period of time, it was thought that that ELA1 / CELA1 was not transcribed into a protein. However it was later discovered that it was expressed in skin keratinocytes.

Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B (CELA3B).

Read more about Pancreatic Elastase:  Isozymes, Use As Diagnostic

Other articles related to "elastase, pancreatic, pancreatic elastase":

Types of Serpins - Human - Table 1
... extracellular, inhibits human neutrophil elastase ... probably extracellular, not characterised Unknown 14q32 SERPINB1 1HLE Monocyte neutrophil elastase inhibitor Intracellular, inhibition of neutrophil elastase Murine knockout results in neutrophil survival ... Studies on the Pequeño mouse line revealed that loss of SERPINI2 results in pancreatic insufficiency through pancreatic acinar cell loss ...
Serine Protease Inhibitors - Types of Serpins - Human - Table 1
7API 1D5S Alpha 1-antitrypsin extracellular, inhibits human neutrophil elastase ... probably extracellular, not characterised Unknown 14q32 SERPINB1 1HLE Monocyte neutrophil elastase inhibitor Intracellular, inhibition of neutrophil elastase Murine knockout results in neutrophil ... Studies on the Pequeño mouse line revealed that loss of SERPINI2 results in pancreatic insufficiency through pancreatic acinar cell loss ...
Pancreatic Elastase - Use As Diagnostic
... The use of Pancreatic Elastase 1 (E1) in Laboratories to Diagnose Exocrine Pancreatic Insufficiency Human pancreatic elastase 1 (E1) remains undegraded during intestinal transit ... Therefore its concentration in feces reflects exocrine pancreatic function ... Thus the quantification of pancreatic elastase 1 in serum allows diagnosis or exclusion of acute pancreatitis ...
List Of EC Numbers (EC 3) - EC 3.4: Act On Peptide Bonds - Peptidase - EC 3.4.21: Serine Proteases
... enteropeptidase EC 3.4.21.10 acrosin EC 3.4.21.11 elastase EC 3.4.21.12 alpha-lytic endopeptidase EC 3.4.21.13 phaseolus proteinase EC 3.4.21.14 microbial ...