Oxytocin/ergometrine

Oxytocin/ergometrine (trade name Syntometrine) is an obstetric combination drug. The components are synthetically produced oxytocin, a human hormone produced in the hypothalamus, and ergometrine, an alpha-adrenergic, dopaminergic and serotonin (5-HT2) receptor agonist.

Both substances cause the uterus to contract. An injection of syntometrine is given in the third stage of labor, just after the birth of the child, to facilitate delivery of the placenta and to prevent postpartum hemorrhage by causing smooth muscle tissue in the blood vessel walls to narrow, thereby reducing blood flow.

Read more about Oxytocin/ergometrine:  Contraindications, Side Effects, Drug Interactions

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... Carbetocin (trade names Duratocin, Pabal, Lonactene) is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth, particularly following Cesarean section ... It is an eight amino long oxytocin analogue (oxytocin is a nonapeptide) and its action is similar to that of oxytocin ...

... Due to carbetocin's considerably longer half-life, its effects are longer lasting than other oxytocin homologs such as Pitocin or Barusiban ... A single carbetocin administration compared to a placebo or an eight hour intravenous drip of oxytocin in a randomized blind study, necessitated significantly less additional oxytocin therapy following a Cesarean section ...

... Virtually all vertebrates have an oxytocin-like nonapeptide hormone that supports reproductive functions and a vasopressin-like nonapeptide hormone involved in water regulation ... The two genes are usually located close to each other (less than 15,000 bases apart) on the same chromosome, and are transcribed in opposite directions (however, in fugu, the homologs are further apart and transcribed in the same direction) ...

... Carter studies social bonding, male and female parental behavior, the social control of stress reactivity and the social control of reproduction, often using animal models such as the socially monogamous prairie vole ... Carter’s research focuses on neuropeptide and steroid hormones, including oxytocin, vasopressin, corticotropin-releasing hormone, and estrogen ...