Oxytocin - Discovery

Discovery

The word oxytocin was derived from Greek ὀξύς, oxys, and τόκος, tokos, meaning "quick birth", after its uterine-contracting properties were discovered by British pharmacologist Sir Henry Hallett Dale in 1906. The milk ejection property of oxytocin was described by Ott and Scott in 1910 and by Schafer and Mackenzie in 1911.

The nine amino acid sequence of oxytocin was elucidated by Vincent du Vigneaud et al. and by Tuppy in 1953 and synthesized biochemically soon after by du Vigneaud et al. in 1953. Oxytocin was the first polypeptide hormone to be sequenced and synthesized.

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