Oxoguanine Glycosylase

Oxoguanine Glycosylase

Identifiers Symbols OGG1; HMMH; HOGG1; MUTM; OGH1 External IDs OMIM: 601982 MGI: 1097693 HomoloGene: 1909 GeneCards: OGG1 Gene EC number

Gene Ontology
Molecular function damaged DNA binding
endonuclease activity
protein binding
microtubule binding
oxidized purine nucleobase lesion DNA N-glycosylase activity
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
Cellular component nucleus
nuclear matrix
nuclear speck
Biological process acute inflammatory response
DNA repair
base-excision repair
base-excision repair, AP site formation
nucleotide-excision repair
regulation of transcription, DNA-dependent
response to oxidative stress
response to radiation
response to estradiol stimulus
regulation of protein import into nucleus, translocation
response to drug
response to ethanol
response to folic acid
cellular response to cadmium ion
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4968 18294 Ensembl ENSG00000114026 ENSMUSG00000030271 UniProt O15527 O08760 RefSeq (mRNA) NM_002542 NM_010957 RefSeq (protein) NP_002533 NP_035087 Location (UCSC) Chr 3:
9.79 – 9.83 Mb Chr 6:
113.33 – 113.34 Mb PubMed search
8-oxoguanine DNA glycosylase, N-terminal domain

structure of catalytically inactive q315a human 8-oxoguanine glycosylase complexed to 8-oxoguanine dna
Symbol OGG_N
Pfam PF07934
Pfam clan CL0407
InterPro IPR012904
SCOP 1ebm
Available protein structures:
Pfam structures
PDBsum structure summary

8-Oxoguanine glycosylase also known as OGG1 is a DNA glycosylase enzyme that, in humans, is encoded by the OGG1 gene. It is involved in base excision repair. It is found in bacterial, archaeal and eukaryotic species.

Read more about Oxoguanine GlycosylaseFunction, Interactions

Other articles related to "oxoguanine glycosylase":

Oxoguanine Glycosylase - Interactions
... Oxoguanine glycosylase has been shown to interact with XRCC1 and PKC alpha. ...