Oxidative Stress

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Further, some reactive oxidative species act as cellular messengers in redox signaling. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling.

In humans, oxidative stress is thought to be involved in the development of many diseases or may exacerbate their symptoms. These include cancer, Parkinson's disease, Alzheimer's disease, atherosclerosis, heart failure, myocardial infarction, Schizophrenia Bipolar disorder, fragile X syndrome, Sickle Cell Disease, lichen planus, vitiligo, autism, and chronic fatigue syndrome. However, reactive oxygen species can be beneficial, as they are used by the immune system as a way to attack and kill pathogens. Short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis.

Read more about Oxidative StressChemical and Biological Effects, Production and Consumption of Oxidants, Oxidative Stress and Diseases, Antioxidants As Supplements, Metal Catalysts, Non-metal Redox Catalysts, Immune Defense

Other articles related to "oxidative stress":

Discovery And Development Of Cyclooxygenase 2 Inhibitors - Cardiovascular Events Associated With Selective COX-2 Inhibitors - Possible Mechanisms
... non-selective NSAIDs and the coxibs produce oxidative stress, indicated by enhanced vascular superoxide(O2-) content and elevated peroxide in plasma, which is in tune with enhanced expression of ... depletion of BH4 can occur with excessive oxidative stress (that can be caused be NSAIDs) and, hence, be the cause of eNOS dysfunction ... uncoupling, causes the production of O2- by eNOS, thereby leading to more oxidative stress produced by eNOS ...
Pathophysiology Of Chronic Fatigue Syndrome - Other Hypotheses - Oxidative Stress
... Oxidative stress, an imbalance between the production of reactive oxygen and a biological system's ability to readily detoxify the reactive intermediates or easily repair the ... Gene expression studies suggest a common link between oxidative stress, immune system dysfunction and potassium imbalance in CFS patients leading to impaired nerve balance, reflected in abnormal heart rate ...
Arsenic Toxicity - Carcinogenicity
... Moreover, arsenic could cause oxidative stress by depleting the cell’s antioxidants, especially the ones containing thiol groups ... in fact be a detoxification pathway with regard to oxidative stress the results showed that the lower the As methylation capacity was, the lower the level of plasma antioxidant ... As reviewed by Kitchin (2001), the oxidative stress theory provides an explanation for the preferred tumor sites connected with arsenic exposure ...
Arsenic Toxicity - Oxidative Stress
... Studies have demonstrated that the oxidative stress generated by arsenic may disrupt the signal transduction pathways of the nuclear transcriptional factors PPAR’s, AP-1, and ... The interference of oxidative stress with signal transduction pathways may affect physiological processes associated with cell growth, metabolic syndrome X, glucose homeostasis, lipid metabolism, obesity, insulin ...

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