Orexin-A - Ongoing Research

Ongoing Research

The subjects of one particular study, rhesus monkeys, were deprived of sleep in durations of 30 to 36 hours, and were immediately assessed in short term memory tasks. The rhesus monkeys were split into a test group and into a control group. The test group was administered orexin-A intravenously, or nasally. The control group was given a placebo. The sleep-deprived monkeys, which were given the nasal form of orexin-A, performed far better than the ones treated with injections. Orexin-A not only restored the monkey’s cognitive abilities but made their brains appear awake in PET scans. The same was not true for the control group, which did not exhibit any changes. The findings of these studies strongly favor an effective way to alleviate cognitive limitations due to sleep loss.

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