Nucleoporin 62

Nucleoporin 62

Identifiers Symbols NUP62; IBSN; SNDI; p62 External IDs OMIM: 605815 MGI: 1351500 HomoloGene: 68773 GeneCards: NUP62 Gene

Gene Ontology
Molecular function chromatin binding
nucleocytoplasmic transporter activity
protein binding
structural constituent of nuclear pore
receptor signaling complex scaffold activity
SH2 domain binding
ubiquitin binding
thyroid hormone receptor binding
Cellular component spindle pole
nuclear envelope
nuclear pore
cytoplasm
ribonucleoprotein complex
nucleocytoplasmic shuttling complex
nuclear membrane
intracellular membrane-bounded organelle
pore complex
Biological process carbohydrate metabolic process
transcription, DNA-dependent
nucleocytoplasmic transport
cell surface receptor signaling pathway
cell death
negative regulation of cell proliferation
hexose transport
hormone-mediated signaling pathway
regulation of signal transduction
regulation of glucose transport
protein transport
glucose transport
viral reproduction
cytokine-mediated signaling pathway
viral reproductive process
negative regulation of apoptotic process
negative regulation of programmed cell death
positive regulation of I-kappaB kinase/NF-kappaB cascade
small molecule metabolic process
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of transcription, DNA-dependent
regulation of Ras protein signal transduction
mRNA transport
transmembrane transport
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23636 18226 Ensembl ENSG00000213024 ENSMUSG00000043858 UniProt P37198 Q63850 RefSeq (mRNA) NM_001193357 NM_053074 RefSeq (protein) NP_001180286 NP_444304 Location (UCSC) Chr 19:
50.41 – 50.43 Mb Chr 7:
44.82 – 44.83 Mb PubMed search

Nucleoporin p62 (p62) is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa followed by modification that involve addition of N-acetylglucosamine residues. followed by association with other complex proteins.

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform.

Read more about Nucleoporin 62:  Structure, Function, Pathology, Interactions, Further Reading

Other articles related to "nucleoporin 62, nucleoporin, nucleoporins, 62":

Nucleoporin 62 - Further Reading
... "Human nucleoporin p62 and the essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organization" ... "Mapping of nucleoporins to the center of the nuclear pore complex by post-embedding immunogold electron microscopy" ... "Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region" ...