Nitroaldol Reaction - General Features

General Features

One of the many features of the Henry Reaction that makes it synthetically attractive is that it utilizes only a catalytic amount of base to drive the reaction. Additionally a variety of bases can be used including ionic bases such as alkali metal hydroxides, alkoxides, carbonates, and sources of fluoride anion (e.g. TBAF) or nonionic organic amine bases including TMG, DBU, DBN, and PAP. It is important to note that the base and solvent used do not have a large influence on the overall outcome of the reaction.

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