Neuraminidase

Neuraminidase enzymes are glycoside hydrolase enzymes (EC 3.2.1.18) that cleave the glycosidic linkages of neuraminic acids. Neuraminidase enzymes are a large family, found in a range of organisms. The best-known neuraminidase is the viral neuraminidase, a drug target for the prevention of the spread of influenza infection. The viral neuraminidases are frequently used as an antigenic determinants found on the surface of the Influenza virus. Some variants of the influenza neuraminidase confer more virulence to the virus than others. Other homologs are found in mammalian cells, which have a range of functions. At least four mammalian sialidase homologs have been described in the human genome (see NEU1, NEU2, NEU3, NEU4).

Neuraminidases, also called sialidases, catalyze the hydrolysis of terminal sialic acid residues from the newly formed virions and from the host cell receptors. Sialidase activities include assistance in the mobility of virus particles through the respiratory tract mucus and in the elution of virion progeny from the infected cell.

Read more about Neuraminidase:  Reaction, Subtypes, Structure, Mechanism, Inhibitors

Other articles related to "neuraminidases, neuraminidase":

History - Tryon Island Anti-influenza Drugs 1969
... are inhibitory to specific viral neuraminidases ... these birds on Tryon Island and a novel N9 neuraminidase was identified ... Crystals of this neuraminidase were later prepared for X-ray diffraction analysis to elucidate the enzyme's three-dimensional structure, yielding information useful to many pharmaceuticals ...
Bacterial Neuraminidase
... Bacterial neuraminidase is type of neuraminidase and a virulence factor for many bacteria including Bacteroides fragilis and Pseudomonas aeruginosa ...
Neuraminidase - Inhibitors
... Neuraminidase inhibitors are useful for combating influenza infection zanamivir, administered by inhalation oseltamivir, administered orally and under research ...
Viral Neuraminidase - Neuraminidase Inhibitors - Neuraminidase Inhibition Resistance
... (amino acid) substitution at position 274 in its neuraminidase protein ... and efficiently determine the correct neuraminidase subtype that is responsible for the drug resistance in order to develop medications that will combat specific strains of influenza ... A new class of neuraminidase inhibitors that covalently attach to the enzyme have shown activity against drug-resistant virus in vitro ...
Mumps Hemagglutinin-neuraminidase
... Mumps hemagglutinin-neuraminidase is a type of Hemagglutinin-neuraminidase produced by mumps ...