Necrosis

Necrosis (from the Greek νεκρός, "dead", νέκρωσις, "death, the stage of dying, the act of killing") is a form of cell injury that results in the premature death of cells in living tissue. Necrosis is caused by factors external to the cell or tissue, such as infection, toxins, or trauma that result unregulated digestion of cell components. In contrast apoptosis is a naturally occurring programmed and targeted cause of cellular death. While apoptosis often provides beneficial effects to the organism, necrosis is almost always detrimental and can be fatal.

Cells that die due to necrosis do not follow the apoptotic signal transduction pathway but rather various receptors are activated that result in the loss of cell membrane integrity and an uncontrolled release of products of cell death into the intracellular space. This initiates an inflammatory response in the surrounding tissue: Nearby phagocytes are prevented from locating and engulfing the dead cells. The result is a build-up of dead tissue and cell debris at, or near, the site of the cell death. A classic example is gangrene. For this reason, it is often necessary to remove necrotic tissue surgically, a process known as debridement.

Read more about NecrosisClassification, Causes, Pathogenesis, Treatment, In Plants

Other articles related to "necrosis":

Clinical Biologist - See Also
... Neoplasia Hemodynamics Ischemia Inflammation Wound healing Cell death Necrosis Liquefactive necrosis Coagulative necrosis Caseous necrosis Fat necrosis Apoptosis Pyknosis Karyorrhexis Karyolysis ...
Necrosis - In Plants
... If calcium is deficient, pectin cannot be synthesized, and therefore the cell walls cannot be bonded and thus an impediment of the meristems ... This will lead to necrosis of stem and root tips and leaf edges ...
Anemic Infarct
... amount of hemorrhage that can seep into the area of ischemic necrosis from adjoining capillary beds ... infarct generally results grossly in a wedge shaped area of necrosis with the apex closest to the occlusion and the base at the periphery of the organ ... Ischemic coagulative necrosis results and fibrosis of the affected area develops from the reparative response beginning at the preserved margins and working its way ...
Spider Bite - Management - Necrosis
... There is no established treatment for necrosis ... Dapsone is commonly used in the USA and Brazil for the treatment of necrosis ...
List Of Papaya Diseases - Viral and Viroid Diseases
... Viral and viroid diseases Apical necrosis Papaya apical necrosis virus Droopy necrosis Papaya droopy necrosis virus Feather leaf Unknown virus Leaf curl Virus suspected Mosaic ...