MSX1

MSX1

Identifiers Symbols MSX1; ECTD3; HOX7; HYD1; STHAG1 External IDs OMIM: 142983 MGI: 97168 HomoloGene: 1836 GeneCards: MSX1 Gene

Gene Ontology
Molecular function RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
p53 binding
sequence-specific DNA binding
Cellular component nucleus
transcription factor complex
Biological process negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
in utero embryonic development
epithelial to mesenchymal transition involved in endocardial cushion formation
muscle organ development
negative regulation of cell proliferation
anterior/posterior pattern specification
mesenchymal cell proliferation
signal transduction involved in regulation of gene expression
apoptotic nuclear changes
negative regulation of cell growth
positive regulation of BMP signaling pathway
forebrain development
midbrain development
protein localization to nucleus
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
embryonic nail plate morphogenesis
middle ear morphogenesis
odontogenesis of dentin-containing tooth
regulation of odontogenesis
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of transcription from RNA polymerase II promoter
stem cell differentiation
protein stabilization
negative regulation of striated muscle cell differentiation
palate development
face morphogenesis
bone morphogenesis
cartilage morphogenesis
mammary gland epithelium development
BMP signaling pathway involved in heart development
negative regulation of transcription regulatory region DNA binding
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4487 17701 Ensembl ENSG00000163132 ENSMUSG00000048450 UniProt P28360 P13297 RefSeq (mRNA) NM_002448 NM_010835 RefSeq (protein) NP_002439 NP_034965 Location (UCSC) Chr 4:
4.86 – 4.87 Mb Chr 5:
37.82 – 37.82 Mb PubMed search

Msh homeobox 1, also known as MSX1, is a protein that in humans is encoded by the MSX1 gene. MSX1 transcripts are not only found in thyrotrope-derived TSH cells, but also in the TtT97 thyrotropic tumor, which is a well differentiated hyperplastic tissue that produces both TSHß- and a-subunits and is responsive to thyroid hormone. MSX1 is also expressed in highly differentiated pituitary cells which until recently was thought to be expressed exclusively during embryogenesis. There is a highly conserved structural organization of the members of the MSX family of genes and their abundant expression at sites of inductive cell–cell interactions in the embryo suggest that they have a pivotal role during early development.

Read more about MSX1:  Function, Interactions

Other articles related to "msx1":

MSX1 - Interactions
... MSX1 has been shown to interact with DLX5, CREB binding protein, Sp1 transcription factor, DLX2, TATA binding protein and Msh homeobox 2 ... LHX2, a LIMtype homeoprotein, is a protein partner for MSX1 in vitro and in cellular extracts ... The interaction between MSX1 and LHX2 is mediated through the homeodomain-containing regions of both proteins ...