Morphogens

Some articles on morphogen, morphogens:

Morphogen - Genes and Signals
... A morphogen spreads from a localized source and forms a concentration gradient across a developing tissue ... In developmental biology, 'morphogen' is rigorously used to mean a signaling molecule that acts directly on cells (not through serial induction) to produce specific cellular responses dependent on morphogen ... Well-known morphogens include Decapentaplegic / Transforming growth factor beta, Hedgehog / Sonic Hedgehog, Wingless / Wnt, Epidermal growth factor, Fibroblast growth factor, and retinoic acid ...
Morphogen - Fruit Fly
... factors such as Bicoid or Hunchback can act as morphogens because they can freely diffuse between nuclei to produce smooth gradients of concentration ... or later Drosophila development, syncytia occur only rarely (such as in skeletal muscle), and morphogens are generally secreted signalling proteins ... an elaborate process of signal transduction to communicate the level of morphogen to the nucleus ...
Embryoid Body - Challenges To Directing Differentiation in EBs
... In contrast to the differentiation of ESCs in monolayer cultures, whereby the addition of soluble morphogens and the extracellular microenvironment can be precisely and ... limitations occur within EBs, creating gradients of morphogens, metabolites, and nutrients ... Therefore, the delivery of morphogens to EBs results in increased heterogeneity and decreased efficiency of differentiated cell populations compared to monolayer cultures ...
French Flag Model
... Model is a conceptual definition of a morphogen, described by Lewis Wolpert in the 1960s ... A morphogen is rigorously defined as a signaling molecule that acts directly on cells (not through serial induction) to produce specific cellular responses dependent on ... During early development, morphogen gradients generate different cell types in distinct spatial order ...
Morphogenesis - Molecular Basis
... Morphogens are soluble molecules that can diffuse and carry signals that control cell differentiation decisions in a concentration-dependent fashion ... Morphogens typically act through binding to specific protein receptors ... Several examples that illustrate the roles of morphogens, transcription factors and cell adhesion molecules in morphogenesis are discussed below ...