Moraxella Catarrhalis - Clinical Significance - Link With Bacteremia

Link With Bacteremia

M. catarrhalis has also been linked with septic arthritis in conjunction with bacteremia, as shown in a case recorded by Philipp Melendez and Royce Johnson in 1991 in the Kern Medical Center in the University of California, Los Angeles. Although there have been cases of bacteremia cased by M. catarrhalis reported before, this was the first instance in which bacteremia caused by M. catarrhalis was also associated with septic arthritis. A microbiological evaluation of the patient (a 41 year old male) revealed that M. catarrhalis was the cause of the disease rather than Neisseria as was previously believed. This was also the second case of M. catarrhalis causing septic arthritis (although in the first case there was no mention of bacteremia).

Along with its relation to septic arthritis, bacteremia is also caused by M. catarrhalis infection. However, bacteremia caused by M. catarrhalis infection can range in severity from a slight fever to lethal sepsis and an associated respiratory tract infection) is usually also identified. In a 1995 case study by John Ioannidasa and his colleagues of bacteremia infections caused by M. catarrhalis, there was a 21% mortality rate among patients. However, this may have been due to a lack of knowledge about the bacterium because of its recent recognition as a pathogen.

In this same study, an infection of high-grade bacteremia was linked with the development of endocarditis. However, the patients without endocarditis in the case study has been related to the background of each patient, especially the existence of other illnesses and any possible immune impairments they may or may not have. Also, although bacteremia caused by M. catarrhalis has been infrequently reported, this may be due to a misdiagnosis or oversight because M. catarrhalis was only recently (1990s) identified as an important pathogen. Many chronic disease in patients with M. catarrhalis bacteremia can be linked to the patients with immune defects or respiratory debility. Similarly, respiratory debility in patients with bacteremic pneumonia caused by M. catarrhalis infection can be linked with increased rates of pharyngeal colonization, enhancement of bacterial adherence to abnormal epithelium, and increased susceptibility of pulmonary parenchyma to infection.

Read more about this topic:  Moraxella Catarrhalis, Clinical Significance

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Moraxella Catarrhalis - Clinical Significance - Link With Bacteremia
... catarrhalis has also been linked with septic arthritis in conjunction with bacteremia, as shown in a case recorded by Philipp Melendez and Royce Johnson in 1991 in the Kern ... Although there have been cases of bacteremia cased by M ... catarrhalis reported before, this was the first instance in which bacteremia caused by M ...

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