Monoclonal Gammopathy

Monoclonal gammopathy is a synonym for paraproteinemia. These are usually found in association with haemic neoplasms, especially multiple myeloma. They also occur in other benign and malignant conditions.

Immune disorders, Immunoproliferative immunoglobulin disorders (D89, 273)
PCDs/PP Plasmacytoma · Multiple myeloma (Plasma cell leukemia) · MGUS · IgM (Macroglobulinemia/Waldenström's macroglobulinemia) · heavy chain (Heavy chain disease) · light chain (Primary amyloidosis)
Other hypergammaglobulinemia Cryoglobulinemia

M: LMC

cell/phys/auag/auab/comp, igrc

imdf/ipig/hyps/tumr

proc, drug (L3/4)

Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)
B cell
(lymphoma,
leukemia)
(most CD19
  • CD20)
By development/
marker
TdT+
  • ALL (Precursor B acute lymphoblastic leukemia/lymphoma)
CD5+
  • naive B cell (CLL/SLL)
mantle zone (Mantle cell)
CD22+
  • Prolymphocytic
  • CD11c+ (Hairy cell leukemia)
CD79a+
  • germinal center/follicular B cell (Follicular
  • Burkitt's
  • GCB DLBCL
  • Primary cutaneous follicular lymphoma)
marginal zone/marginal-zone B cell (Splenic marginal zone
  • MALT
  • Nodal marginal zone
  • Primary cutaneous marginal zone lymphoma)
RS (CD15+, CD30+)
  • Classic Hodgkin's lymphoma (Nodular sclerosis)
  • CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)
PCDs/PP
(CD38+/CD138+)
  • see immunoproliferative immunoglobulin disorders
By infection
  • KSHV (Primary effusion)
  • EBV (Lymphomatoid granulomatosis
  • Post-transplant lymphoproliferative disorder)
  • HIV (AIDS-related lymphoma)
  • Helicobacter pylori (MALT lymphoma)
Cutaneous
  • Diffuse large B-cell lymphoma
  • Intravascular large B-cell lymphoma
  • Primary cutaneous marginal zone lymphoma
  • Primary cutaneous immunocytoma
  • Plasmacytoma
  • Plasmacytosis
  • Primary cutaneous follicular lymphoma
T/NK
T cell
(lymphoma,
leukemia)
(most CD3
  • CD4
  • CD8)
By development/
marker
  • TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)
  • prolymphocyte (Prolymphocytic)
  • CD30+ (Anaplastic large-cell lymphoma
  • Lymphomatoid papulosis type A)
Cutaneous
MF+variants
  • indolent: Mycosis fungoides
  • Pagetoid reticulosis
  • Granulomatous slack skin

aggressive: Sézary's disease

  • Adult T-cell leukemia/lymphoma
Non-MF
  • CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
  • Pleomorphic T-cell lymphoma
  • Lymphomatoid papulosis type B

CD30+: CD30+ cutaneous T-cell lymphoma

Other peripheral
  • Hepatosplenic
  • Angioimmunoblastic
  • Enteropathy-associated T-cell lymphoma
  • Peripheral T-cell lymphoma-Not-Otherwise-Specified (Lennert lymphoma)
  • Subcutaneous T-cell lymphoma
By infection
  • HTLV-1 (Adult T-cell leukemia/lymphoma)
NK cell/
(most CD56)
T or NK
  • EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma)
  • Large granular lymphocytic leukemia
Lymphoid+myeloid
  • Acute biphenotypic leukaemia
Lymphocytosis
  • Lymphoproliferative disorders (X-linked lymphoproliferative disease
  • Autoimmune lymphoproliferative syndrome)
  • Leukemoid reaction
  • Diffuse infiltrative lymphocytosis syndrome
Cutaneous lymphoid hyperplasia
  • Cutaneous lymphoid hyperplasia with bandlike and perivascular patterns
  • Cutaneous lymphoid hyperplasia with nodular pattern
  • Jessner lymphocytic infiltrate of the skin

M: LMC

cell/phys/auag/auab/comp, igrc

imdf/ipig/hyps/tumr

proc, drug (L3/4)

Other articles related to "monoclonal gammopathy":

Monoclonal Gammopathy Of Undetermined Significance
... Monoclonal gammopathy of undetermined significance (MGUS, unknown or uncertain may be substituted for undetermined), formerly benign monoclonal gammopathy, is a condition in which a paraprotein is found in ...