Minor histocompatibility antigen (a.k.a. MiHA) are receptors on the cell surface of donated organs that are known to give an immunological response in some organ transplants. They cause problems of rejection less frequently than those of the major histocompatibility complex (MHC).
Minor histocompatibility antigens are due to normal proteins that are in themselves polymorphic in a given population. Even when a transplant donor and recipient are identical with respect to their major histocompatibility complex genes, the amino acid differences in minor proteins can cause the grafted tissue to be slowly rejected.
Read more about Minor Histocompatibility Antigen: Clinical Implications
Other articles related to "minor histocompatibility antigen, minor histocompatibility, antigens":
... Immunization of mothers against male-specific minor histocompatibility (H-Y) antigens has a pathogenic role in many cases of secondary recurrent miscarriage, that is, recurrent ...
Famous quotes containing the word minor:
“A child who fears excessive retaliation for even minor offenses will learn very early on that to lie is to protect himself.... If your child intuits that you will react very punitively to his wrongdoing, he may be tempted to lie and may become, as time goes on, a habitual liar.”
—Lawrence Balter (20th century)