Epidemiology and Disease Associations
McLeod syndrome is present in 0.5 to 1 per 100,000 the population. McLeod males have variable acanthocytosis due to a defect in the inner leaflet bilayer of the red blood cell, as well as mild hemolysis. McLeod females have only occasional acanthocytes and very mild hemolysis; the lesser severity is thought to be due to X chromosome inactivation via the Lyon effect. Some individuals with McLeod phenotype develop myopathy, neuropathy or psychiatric symptoms, producing a syndrome that may mimic chorea.
McLeod syndrome can cause an increase in the enzymes creatine kinase (CK) and lactate dehydrogenase (LDH) found in routine blood screening.
Read more about this topic: Mc Leod Syndrome
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