Mannose Phosphate Isomerase

Mannose Phosphate Isomerase

Mannose-6 phosphate isomerase (MPI), alternately phosphomannose isomerase (PMI) (EC:5.3.1.8) is an enzyme which facilitates the interconversion of fructose 6-phosphate(F6P) and mannose-6-phosphate(M6P). Mannose-6-Phosphate Isomerase may also enable the synthesis of GDP-mannose in eukaryotic organisms. M6P can be converted to F6P by Mannose-6-Phosphate Isomerase and subsequently utilized in several metabolic pathways including Glycolysis and capsular polysaccharide biosynthesis. PMI is monomeric and metallodependent on Zinc as a cofactor ligand. PMI is inhibited by erythrose 4-phosphate, mannitol 1-phosphate, and to a lesser extent, the alpha anomer of M6P.

Read more about Mannose Phosphate Isomerase:  Mechanism, Structure, Biological Relevance, Medical Relevance

Other articles related to "mannose, phosphate, phosphates":

Mannose-1-phosphate Guanylyltransferase (GDP) - Other Common Names
... GDP mannose phosphorylase Mannose 1-phosphate (guanosine diphosphate) guanylyltransferase GDP mannose phosphorylase GDP-mannose 1-phosphate guanylyltransferase Guanosine ...
Phosphate - Ecology
... of its important role in biological systems, phosphate is a highly sought after resource ... Addition of high levels of phosphate to environments and to micro-environments in which it is typically rare can have significant ecological consequences ... In the context of pollution, phosphates are one component of total dissolved solids, a major indicator of water quality, but not all phosphorus is in a molecular form which algae can ...
Triose Phosphate Translocator
... The triose phosphate translocator is an integral membrane protein found in the inner membrane of chloroplasts ... It exports triose phosphate (Dihydroxyacetone phosphate) in exchange for inorganic phosphate and is therefore classified as an antiporter ... The imported phosphate is then used for ATP regeneration via the light-dependent-reaction the ATP may then for example be used for further reactions in the Calvin-cycle.The ...
Transaldolase B
... (EC 2.2.1.2) of the non-oxidative phase of the pentose phosphate pathway ... The following chemical reaction is catalyzed by transaldolase sedoheptulose 7-phosphate + glyceraldehyde 3-phosphate erythrose 4-phosphate + fructose 6-pho ...
Transaldolase B - Clinical Significance
... The pentose phosphate pathway has two metabolic functions (1) generation of nicotinamide adenine dinucleotide phosphate (reduced NADPH), for reductive biosynthesis, and (2) formation of ribose which is an ... Transaldolase links the pentose phosphate pathway to glycolysis ... an accumulation of erythritol (from erythrose 4-phosphate), D-arabitol, and ribitol ...