Mannich Reaction - Applications

Applications

The Mannich-Reaction is employed in the organic synthesis of natural compounds such as peptides, nucleotides, antibiotics, and alkaloids (e.g. tropinone). Other applications are in agro chemicals such as plant growth regulators, paint- and polymer chemistry, catalysts and main mechanism of formalin tissue crosslinking.

The Mannich reaction is also used in the synthesis of medicinal compounds e.g. rolitetracycline (Mannich base of tetracycline), fluoxetine (antidepressant), tramadol, and tolmetin (anti-inflammatory drug).

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