Mannich

Some articles on mannich:

Alkaloid - Biosynthesis - Mannich Reaction
... An integral component of the Mannich reaction, in addition to an amine and a carbonyl compound, is a carbanion, which plays the role of the nucleophile in the nucleophilic ... The Mannich reaction can proceed both intermolecularly and intramolecularly ...
Mannich Base
... A mannich base is a beta-amino-ketone, which is formed in the reaction of an amine, formaldehyde (or an aldehyde) and a carbon acid ... The Mannich base is an endproduct in the Mannich reaction, which is nucleophilic addition reaction of a non-enolizable aldehyde and any primary or secondary amine to produce resonance stabilized ... carbonyl compound, amide, carbamate, hydantoin or urea) to the imine gives the Mannich base ...
Mannich Reaction - Applications
... The Mannich-Reaction is employed in the organic synthesis of natural compounds such as peptides, nucleotides, antibiotics, and alkaloids (e.g ... The Mannich reaction is also used in the synthesis of medicinal compounds e.g ... rolitetracycline (Mannich base of tetracycline), fluoxetine (antidepressant), tramadol, and tolmetin (anti-inflammatory drug) ...
Asymmetric Mannich Reactions
... Progress has been made towards asymmetric Mannich reactions ... When properly functionalized the newly formed ethylene bridge in the Mannich adduct has two prochiral centers giving rise to two diastereomeric pairs of enantiomers ... The first asymmetric Mannich reaction with an unmodified aldehyde was carried with (S)-proline as a naturally occurring chiral catalyst ...