Lyme Disease Microbiology

Lyme Disease Microbiology

Lyme disease, or borreliosis, is caused by spirochetal bacteria from the genus Borrelia, which has at least 37 known species, 12 of which are Lyme related, and an unknown number of genomic strains. Borrelia species known to cause Lyme disease are collectively known as Borrelia burgdorferi sensu lato.

Borrelia are microaerophilic and slow-growing—the primary reason for the long delays when diagnosing Lyme disease—and have been found to have greater strain diversity than previously estimated. The strains differ in clinical symptoms and/or presentation as well as geographic distribution.

Except for Borrelia recurrentis (which causes louse-borne relapsing fever and is transmitted by the human body louse), all known species are believed to be transmitted by ticks.

Read more about Lyme Disease Microbiology:  Species and Strains, Epidemiology, Life Cycle, Genomic Characteristics, Structure and Growth, Outer Surface Proteins, Mechanisms of Persistence, Advancing Immunology Research, Vaccines

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Lyme Disease Microbiology - Vaccines
... Recently, considerable progress in the development of broadly protective Lyme disease vaccines has been made ... developing vaccines that specifically target the tick vectors of Lyme disease, specifically components of tick saliva that coat the bacteria ... While an effective Lyme disease vaccine seems likely to be developed, earlier experiences with the LYMErix vaccine suggest that bringing such a vaccine to market will be a challenge ...

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