Long Ncrnas

Some articles on long ncrnas, ncrnas, ncrna:

Long Non-coding RNA - Long NcRNA Functions - Long NcRNAs in The Regulation of Gene Transcription - Long NcRNAs Regulating Basal Transcription Machinery
... NcRNAs also target general transcription factors required for the RNAP II transcription of all genes (Goodrich 2006) ... A ncRNA transcribed from an upstream minor promoter of the dihydrofolate reductase (DHFR) gene forms a stable RNA-DNA triplex within the major promoter of DHFR to prevent the binding of the ... The U1 ncRNA can induce transcription initiation by specifically binding to and stimulating TFIIH to phosphorylate the C-terminal domain of RNAP II (Kwek 2002) ...
Long Non-coding RNA - Long NcRNA Functions - Long NcRNAs in Epigenetic Regulation
... In Drosophila, long ncRNAs induce the expression of the homeotic gene, Ubx, by recruiting and directing the chromatin modifying functions of the trithorax ... the human Hox genes are associated with hundreds of ncRNAs that are sequentially expressed along both the spatial and temporal axes of human development and define chromatin domains of ... One ncRNA, termed HOTAIR, that originates from the HOXC locus represses transcription across 40 kb of the HOXD locus by altering chromatin trimethylation state ...
Long Non-coding RNAs in Disease
... Recent recognition that long ncRNAs function in various aspects of cell biology has focused increasing attention on their potential to contribute towards disease ... A handful of studies have implicated long ncRNAs in a variety of disease states and support an involvement and co-operation in oncogenesis ... While many association studies have identified long ncRNAs that are aberrantly expressed in disease states, we have little understanding of their ...

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