List of Bestselling Drugs

The following is a list of the top 100 pharmaceutical products ranked by sales in U.S. dollars for Q4 2012.

Rank Brand Name(s) Generic Name Sales Q3 2012 Change from Q2 2012 Company(ies) Disease/Medical Use First Approval Date Patent Expiration Date
1 Nexium Esomeprazole 1,420,907 2.93% AstraZeneca Gastrointestinal disorders Mar-2000 May-2014
2 Abilify Aripiprazole 1,405,226 1.89% Otsuka Pharmaceutical, Bristol-Myers Squibb Psychosis, Depression Nov-2002 Oct-2014
3 Crestor Rosuvastatin 1,245,527 10.74% AstraZeneca, Shionogi Cholesterol Nov-2002 Jul-2016
4 Cymbalta Duloxetine 1,158,353 9.50% Eli Lilly and Company Depression, Anxiety disorders Aug-2004 Dec-2013
5 Humira Adalimumab 1,152,261 13.45% Abbott Laboratories Rheumatoid arthritis Dec-2002 Dec-2016
6 Advair Diskus, Seretide Fluticasone + Salmeterol 1,148,611 2.10% GlaxoSmithKline Asthma Aug-2000 Mar-2012
7 Enbrel Etanercept 1,066,697 12.51% Amgen Rheumatoid arthritis Nov-1998 Oct-2012
8 Remicade Infliximab 952,068 2.02% Johnson & Johnson, Merck & Co., Inc., Mitsubishi Tanabe Pharma Crohn's disease, Rheumatoid arthritis Aug-1998 n/a
9 Copaxone Glatiramer 877,591 9.93% Teva Pharmaceutical Industries, Sanofi-Aventis Multiple sclerosis Dec-1996 Nov-2014
10 Neulasta Filgrastim 832,784 -1.17% Amgen Neutropenia Jan-2002 Mon-20XX
11 Rituxan, MabThera Rituximab 773,460 -5.61% Roche, Genentech, Biogen Idec, Chugai Pharmaceutical Non-Hodgkin’s lymphoma, Rheumatoid arthritis Nov-1997 Mon-20XX
12 Atripla Emtricitabine/tenofovir/efavirenz 692,246 1.34% Gilead Sciences, Inc. HIV infection Dec-1996 Mar-2015
13 OxyContin Oxycodone 679,924 -0.55% Purdue Pharma Pain Dec-1996 Mon-20XX
14 Spiriva Tiotropium 669,882 1.31% Boehringer Ingelheim Chronic obstructive pulmonary disease Apr-2002 Jul-2018
15 Januvia sitagliptin 651,299 7.50% Merck & Co., Inc. Diabetes Dec-1996 Nov-2017
16 Avastin Bevacizumab 650,363 0.41% Roche, Genentech Colorectal cancer Feb-2004 Mon-20XX
17 Lantus Insulin analog (Insulin glargine) 556,147 4.94% Sanofi-Aventis Type 2 diabetes and type 1 diabetes Apr-2000 Dec-2011
18 Truvada Tenofovir + Emtricitabine 551,280 1.56% Gilead Sciences HIV infection Aug-2004 Mon-20XX
19 Lantus Solostar Insulin analog (Insulin glargine) 535,660 11.36% Sanofi-Aventis Type 2 diabetes and type 1 diabetes Apr-2000 Dec-2011
20 Epogen Erythropoietin 526,118 -5.18% Amgen Anemia Jun-1989 Mon-20XX
21 Lyrica Pregabalin 499,777 9.94% Pfizer Neuropathic pain Jul-2004 Jul-2019
22 Celebrex Celecoxib 492,984 12.77% Pfizer Osteoarthritis and rheumatoid arthritis Dec-1998 May-2014
23 Singulair Montelukast 486,837 -62.20% Merck & Co. Asthma Feb-1998 Aug-2012
24 Diovan Valsartan 469,299 -4.29% Novartis Hypertension Dec-1996 Sep-2012
25 Gleevec, Glivec Imatinib 454,935 10.57% Novartis Leukemia May-2001 Jan-2015
26 Herceptin Trastuzumab 450,251 -0.84% Roche, Genentech, Chugai Pharmaceutical Breast cancer Sep-1998 Mon-20XX
27 Namenda Memantine 432,634 6.05% Forest Laboratories Alzheimer disease Oct-2003 Apr-2014
28 Suboxone Buprenorphine 392,977 14.63% Reckitt Benckiser Pharmaceuticals Inc. Acute Withdrawal Symptoms Aug-2000 Mon-20XX
29 Avonex Interferon beta-1a 392,159 -5.34% Biogen Idec Multiple sclerosis May-1996 Mon-20XX
30 Enoxaparin Enoxaparin 388,188 -15.96% Generic Deep-vein thrombosis Mar-1993 Aug-2012
31 Lucentis Ranibizumab 382,048 -1.88% Genentech, Inc Anemia Dec-1990 Mon-20XX
32 Escitalopram Escitalopram 416,370 16% Generic, H. Lundbeck Depression, Anxiety disorders Aug-2002 Mar-2012
33 One Touch Ultra ] 374,548 3.43% ] Diabetes testing supplies Dec-1990 Mon-20XX
34 Diovan HCT Valsartan 372,714 -7.39% Novartis Hypertension Dec-1996 Sep-2012
35 Vyvanse Lisdexamfetamine 365,023 -2.81% Shire US Inc Attention Deficit Disorder/Sleepiness Dec-1990 Mon-20XX
36 Zetia Ezetimibe 360,711 7.06% Merck & Co., Schering-Plough Cholesterol Oct-2002 Oct-2017
37 AndroGel Testosterone Gel 347,674 6.38% Abbott Laboratories, Schering-Plough Low testosterone levels Oct-2002 Oct-2016
38 Methylphenidate Methylphenidate 346,945 0.01% Generic Attention-deficit hyperactivity disorder Aug-2000 Mon-20XX
39 Actos Pioglitazone 333,494 -41.96% Takeda Pharmaceutical, Eli Lilly and Company Type 2 diabetes Jul-1999 May-2011
40 Lidoderm Lidocaine 326,812 6.92% Endo Pharmaceuticals Pain Mar-1999 Mon-20XX
41 TriCor, Lipanthyl Fenofibrate 309,635 6.40% Abbott Laboratories, Solvay Cholesterol Feb-1998 Mon-20XX
42 Rebif Interferon beta-1a 308,352 8.88% Serono Multiple sclerosis Feb-1998 Mon-20XX
43 Symbicort Budesonide + Formoterol 307,678 4.37% AstraZeneca Asthma Aug-2000 Mon-20XX
44 Novolog Insulin aspart + Salbutamol 293,893 8.83% Novo Nordisk Chronic obstructive pulmonary disease Oct-1996 Mon-20XX
45 Incivek Erythropoietin 293,018 -18.72% Johnson & Johnson Anemia Dec-1990 Mon-20XX
46 Seroquel XR Quetiapine 284,299 6.05% AstraZeneca Schizophrenia, Bipolar Disorder Sep-1997 Mar-2012
47 Alimta Pemetrexed 276,306 -1.39% Eli Lilly and Company Non-small cell lung cancer Feb-2004 Mon-20XX
48 Viagra Sildenafil 276,085 7.82% Pfizer Erectile dysfunction Mar-1998 Mar-2012
49 Levemir, Insulin detemir Insulin detemir 274,892 7.66% Novo Nordisk Diabetes Dec-1990 Mon-20XX
50 amphetaminedextroamphetamine amphetamine+dextroamphetamine 272,504 -0.97% Generic Attention Deficit DIsorder/Sleepiness Feb-2004 Mon-20XX
51 NovoLog FlexPen Insulin aspart 270,735 11.89% Novo Nordisk Diabetes Oct-1996 Mon-20XX
52 ProAir HFA Salbutamol 267,692 12.06% Teva Pharmaceuticals Chronic obstructive pulmonary disease, asthma Oct-1996 Mon-20XX
53 Lovaza Darbepoetin alfa 266,568 8.82% GlaxoSmithKline lower very high triglyceride Jun-2001 Mon-20XX
54 Combivent Ipratropium + Salbutamol 265,411 -1.79% Boehringer Ingelheim Chronic obstructive pulmonary disease Oct-1996 Mon-20XX
55 Varivax Oka/Merck strain of live 263,952 31.34% Merck & Co., Inc. Anemia Dec-1990 Mon-20XX
56 Niaspan Niacin 262,879 4.70% Kos Pharmaceuticals Cholesterol Jul-1997 Mon-20XX
57 Procrit, Eprex Erythropoietin 262,659 -10.20% Johnson & Johnson Anemia Dec-1990 Mon-20XX
58 Humalog Insulin analog 251,389 8.03% Eli Lilly and Company Diabetes Apr-1996 Mon-20XX
59 Metoprolol Metoprolol 249,769 -0.87% Generic Hypertension Jan-1992 Mon-20XX
60 Neupogen Filgrastim 248,423 2.65% Amgen Neutropenia Feb-1991 Mon-20XX
61 Nasonex Mometasone 247,294 -9.30% Schering-Plough Allergic rhinitis Oct-1997 Oct-2018
62 Flovent HFA Fluticasone 237,214 -2.46% GlaxoSmithKline Asthma Mar-1996 Mon-20XX
63 Reyataz Atazanavir 236,127 1.20% Bristol-Myers Squibb HIV infection Jan-2003 Mon-20XX
64 Isentress Raltegravir 233,391 2.58% Merck & Co., Inc. HIV Infection Dec-1998 Mon-20XX
65 Vytorin Ezetimibe + Simvastatin 228,895 6.33% Merck & Co., Schering-Plough Cholesterol Jul-2004 Mon-20XX
66 Modafinil Modafinil 228,428 -0.79% Generic Sleepiness Dec-1998 Mon-20XX
67 Janumet metformin + sitagliptin 228,307 5.21% Merck & Co., Inc. type 2 diabetes Dec-1998 Mon-20XX
68 Cialis Tadalafil 226,446 9.05% Eli Lilly and Company, Lilly Icos Erectile dysfunction Nov-2002 Mon-20XX
69 acetaminophen/hydrocodone acetaminophen/hydrocodone + Formoterol 226,379 18.96% Generic Asthma/analgesia Aug-2000 Mon-20XX
70 Gilenya fingolimod 221,299 21.19% Novartis Corporation Multiple sclerosis Feb-2000 Jan-2007
71 Aranesp Insulin detemir 219,796 -1.51% Amgen Inc. Anemia Jun-2001 Mon-20XX
72 Restasis cyclosporine ophthalmic emulsion 217,097 7.35% Allergan, Inc, Lilly Icos Chronic Dry Eye and Inflammation Nov-2002 Mon-20XX
73 AcipHex, Pariet Rabeprazole 215,681 10.07% Eisai, Johnson & Johnson Gastrointestinal disorders Aug-1999 Nov-2013
74 Victoza Levothyroxine 209,163 27.22% Novo Nordisk Hypothyroidism May-1909 Mon-20XX
75 Pradaxa Dabigatran Etexilate 209,063 3.84% Boehringer Ingelheim Pharmaceuticals, Inc, Lilly Icos Oral Anticoagulant Oct-2010 Mon-20XX
76 Orencia Budesonide + Formoterol 203,359 6.17% Bristol-Myers Squibb Company Asthma Aug-2000 Mon-20XX
77 Betaseron, Betaferon Interferon beta-1b 203,170 11.98% Schering AG Multiple sclerosis Jul-1993 Mon-20XX
78 Eloxatin, Eloxatine Oxaliplatin 203,067 -55.33% Sanofi-Aventis Colorectal cancer Aug-2002 Aug-2016
79 VESIcare vaccine 201,552 9.64% Astellas Pharma US Pneumococcal disease Feb-2000 Jan-2007
80 Dexilant Dexlansoprazole 200,149 13.25% Takeda Pharmaceuticals North America, Inc Gastrointestinal disorders Dec-2004 Jul-2012
81 Adderall XR Amphetamine 197,947 -7.81% Shire Pharmaceuticals Attention-deficit hyperactivity disorder Oct-2001 Mon-20XX
82 Fentanyl Fentanyl 196,777 -0.39% Generic Pain Aug-1990 Mon-20XX
83 Prezista Rabeprazole 196,751 1.17% Eisai, Johnson & Johnson Gastrointestinal disorders Aug-1999 May-2013
84 Zostavax Zostavax 194,633 1.17% Eisai, Merck & Co. live vaccine Aug-1999 May-2013
85 Evista Raloxifene 189,378 9.53% Eli Lilly and Company, Chugai Pharmaceutical Osteoporosis Dec-1997 Jan-2013
86 Benicar, Olmetec Olmesartan 188,980 9.67% Daiichi Sankyo, Forest Laboratories Hypertension Apr-2002 Apr-2016
87 Gardasil, Silgard Olmesartan 188,952 0% Merck & Co., Forest Laboratories human papillomavirus Apr-2002 Apr-2016
88 Lipitor Atorvastatin 186,508 -67.80% Pfizer Cholesterol Dec-1996 Nov-2011
89 budesonide Budesonide + budesonide 186,479 -3.36% Generic Asthma Aug-2000 Mon-20XX
90 Synthroid Levothyroxine 185,868 12.61% Abbott Laboratories Hypothyroidism May-1909 Mon-20XX
91 Xolair Omalizumab 184,317 0% -- Hypothyroidism May-1909 Mon-20XX
92 Renvela Olmesartan 183,699 7.39% Genzyme Corporation, Forest Laboratories Hypertension Apr-2002 Apr-2016
93 Lunesta Eszopiclone 183,190 2.23% Sepracor Insomnia Dec-2004 Mon-20XX
94 Prevnar 13 vaccine 177,527 -5.86% Wyeth Pneumococcal disease Feb-2000 Jan-2007
95 Xeloda Capecitabine 176,414 5.28% Roche, Chugai Pharmaceutical Cancer Jun-1909 Mon-20XX
96 EpiPen 2-Pak EpiPen 2-Pak 174,048 0% Dey Pharma Anaphylaxis Apr-2000 Mon-20XX
97 Sensipar Sensipar 172,317 -1.37% Amgen Inc. Secondary Hyperparathyroidism Apr-2000 Mon-20XX
98 Zyvox Linezolid 171,755 -1.37% Pfizer Bacterial infections Apr-2000 Mon-20XX
99 Atorvastatin Atorvastatin 170,506 -78.25% Generic Cholesterol Dec-1996 Nov-2011
100 Stelara Ustekinumab 169,648 -1.37% Pfizer inflammatory disorders Apr-2000 Mon-20XX
101 Aranesp Darbepoetin alfa 150,161 26% Amgen Anemia Jun-2001 Mon-20XX
102 Aranesp Darbepoetin alfa 145,854 26% Merck & Co., Inc. Anemia Jun-2001 Mon-20XX
103 Velcade Tadalafil 123,741 30% Takeda Pharmaceuticals North America, Inc, Lilly Icos Erythema nodosum leprosum Nov-2002 Mon-20XX
104 Pradaxa Tadalafil 110,962 30% Merck & Co., Inc., Lilly Icos Erectile dysfunction Nov-2002 Mon-20XX
105 Erbitux Cetuximab 115,854 56% Bristol-Myers Squibb, Merck KGaA Colorectal cancer Feb-2004 Mon-20XX
106 Ventolin HFA Levothyroxine 110,732 -4% GlaxoSmithKline Hypothyroidism May-1909 Mon-20XX
107 Protonix, Pantozol, Pantoloc Pantoprazole 100,050 4% Wyeth, Altana, Solvay Gastrointestinal disorders Feb-2000 Mon-20XX
108 Tamiflu Oseltamivir 100,000 69% Roche, Chugai Pharmaceutical, Hetero Drugs Influenza Oct-1999 Mon-20XX

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    The advice of their elders to young men is very apt to be as unreal as a list of the hundred best books.
    Oliver Wendell Holmes, Jr. (1841–1935)

    Razors pain you;
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    Guns aren’t lawful;
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    We saw the machinery where murderers are now executed. Seven have been executed. The plan is better than the old one. It is quietly done. Only a few, at the most about thirty or forty, can witness [an execution]. It excites nobody outside of the list permitted to attend. I think the time for capital punishment has passed. I would abolish it. But while it lasts this is the best mode.
    Rutherford Birchard Hayes (1822–1893)