The lipid hypothesis was one of two hypotheses (the other being the chronic endothelial injury hypothesis) developed in the 1850s to explain the pathogenesis of atherosclerosis. It proposes a connection between plasma cholesterol level and the development of coronary heart disease.
It was proposed by the German pathologist Rudolf Virchow in 1856 and suggested that blood lipid accumulation in arterial walls causes atherosclerosis. Since the emergence of cardiovascular disease as a major cause of death in the Western world in the middle of the 20th century, the lipid hypothesis received greater attention. An accumulation of evidence has led to the acceptance of the lipid hypothesis as scientific fact by the medical community; however, a small but vocal minority contend that it has not yet been properly validated, and that vascular inflammatory mechanisms prevail independent of blood cholesterol levels.
Other articles related to "lipid hypothesis, lipid":
... Since the 1950s, the lipid hypothesis (also known as the "Diet-Heart Idea"), which posits that saturated fat and high cholesterol play a role in the causation of atherosclerosis and ... there is scientific consensus that the lipid hypothesis has been validated ... heart attacks has been seen as further validation of the lipid hypothesis ...
... In plants and microbes, changes in the lipid composition of cell membranes have been linked to cold tolerance ... The changes in membrane lipid composition lead to a higher membrane fluidity, thus keeping the membrane from "freezing" at low temperatures ... This "lipid hypothesis of cold tolerance" is less well supported in animals ...
Famous quotes containing the word hypothesis:
“On pragmatistic principles, if the hypothesis of God works satisfactorily in the widest sense of the word, it is true.”
—William James (18421910)