Identifiers Symbols LIG1; MGC117397; MGC130025 External IDs OMIM: 126391 MGI: 101789 HomoloGene: 197 ChEMBL: 5694 GeneCards: LIG1 Gene EC number

Gene Ontology
Molecular function DNA binding
DNA ligase activity
DNA ligase (ATP) activity
ATP binding
metal ion binding
Cellular component nucleus
Biological process S phase of mitotic cell cycle
mitotic cell cycle
telomere maintenance via recombination
telomere maintenance
double-strand break repair via homologous recombination
DNA metabolic process
DNA strand elongation involved in DNA replication
lagging strand elongation
DNA repair
transcription-coupled nucleotide-excision repair
base-excision repair
nucleotide-excision repair
nucleotide-excision repair, DNA gap filling
double-strand break repair
anatomical structure morphogenesis
telomere maintenance via semi-conservative replication
V(D)J recombination
DNA ligation involved in DNA repair
cell division
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3978 16881 Ensembl ENSG00000105486 ENSMUSG00000056394 UniProt P18858 P37913 RefSeq (mRNA) NM_000234 NM_001083188 RefSeq (protein) NP_000225 NP_001076657 Location (UCSC) Chr 19:
48.62 – 48.67 Mb Chr 7:
13.28 – 13.31 Mb PubMed search

DNA ligase 1 is an enzyme that in humans is encoded by the LIG1 gene. DNA ligases are important tools for DNA replication and repair in living organisms. There are two families of DNA ligases, ATP-dependent DNA ligases and NAD+ dependent DNA ligases. Dependence upon ATP or NAD+ is conferred in the ligase-adenylate formation and which substrate is to be used. ATP dependent ligases are found in eukaryotes, while NAD+ dependent ligases are found in prokaryotes. DNA ligase I is found in eukaryotes and therefore is in the family of ATP-dependent DNA ligases.

Read more about LIG1:  Discovery, Recruitment and Regulation, Function and Mechanism, Role in Damaged Base Repair, Clinical Signficance

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LIG1 - Clinical Signficance
... Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents ...