Leukotriene

Leukotriene

Leukotrienes are fatty signaling molecules. They were first found in leukocytes (hence their name). One of their roles (specifically, leukotriene D4) is to trigger contractions in the smooth muscles lining the trachea; their overproduction is a major cause of inflammation in asthma and allergic rhinitis. Leukotriene antagonists are used to treat these diseases by inhibiting the production or activity of leukotrienes.

Leukotrienes produced within a cell convey signals that act either on the cell producing them (autocrine signalling) or on vicinal cells (paracrine signalling) to regulate the immune response.

Leukotrienes are naturally produced eicosanoid lipid mediators. They are produced in the body from arachidonic acid by the enzyme 5-lipoxygenase. Their production usually accompanies the production of histamine.

Read more about LeukotrieneTypes, History and Name, Leukotrienes in Asthma

Other articles related to "leukotriene, leukotrienes":

Leukotriene-B4 20-monooxygenase
... In enzymology, a leukotriene-B4 20-monooxygenase (EC 1.14.13.30) is an enzyme that catalyzes the chemical reaction (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H ... Other names in common use include leukotriene-B4 20-hydroxylase, leucotriene-B4 omega-hydroxylase, LTB4 20-hydroxylase, and LTB4 omega-hydroxylase ...
Leukotriene Receptor Antagonist-associated Churg–Strauss Syndrome
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Leukotriene B4 Receptor 2
... Leukotriene B4 receptor 2 is a protein that in humans is encoded by the LTB4R2 gene ... This is a low-affinity receptor for leukotrienes, especially leukotriene B4 ...
Leukotriene E4
... Leukotriene E4 is a cysteinyl leukotriene involved in inflammation ... conversion of LTC4 to LTD4 and then to LTE4, which is the final and most stable cysteinyl leukotriene ... in breath condensation, in plasma, and in urine, making it the dominate cysteinyl leukotriene detected in biologic fluids ...