It Girl, 2009–present
Stone was also photographed alongside Malgosia Bela, Daria Werbowy, Randal Moore, Mariacarla Boscono, Emanuela de Paula, and Isabeli Fontana for the 2009 Pirelli Calendar.
In the February 2009 edition of Vogue Paris, which featured Stone on the cover, she said she does not like the runway and that her unusually small feet for a person her size do not fit in shoes. Stone was featured on the August 2009 cover of W, declaring her "Fashion's It Girl" and why she's the most-wanted face and body in the business. Vogue Paris named her as one of the top 30 models of the 2000s. Stone made her American Vogue debut on the May 2009 cover alongside Liya Kebede, Anna Jagodzinska, Natalia Vodianova, Caroline Trentini, Jourdan Dunn, Raquel Zimmermann, Sasha Pivovarova, Natasha Poly, Karen Elson, and Isabeli Fontana as one of the "Faces of the Moment". It was also a special issue because the cover featured models instead of celebrities. Though following her great success came an international racial controversy when she appeared in an editorial for French's Vogue October 2009 issue with her face and body blackened.
In 2010, Stone replaced Sasha Pivovarova as the new face for Prada's fragrance, Infusion d’Iris, shot by Steven Meisel. Her other spring/summer campaigns included Louis Vuitton, Versus by Versace Fragrance, Jaeger, and H&M. This same year her look sparked a trend in blonde, gap-toothed, big-lipped models like Georgia May Jagger, Lindsey Wixson, and Ashley Smith. The look even inspired Tyra Banks to have a contestant's tooth gap widened on cycle 15 of America's Next Top Model.
Stone made fashion history signing an exclusive deal with Calvin Klein Inc., making the 26-year-old model the face of Calvin Klein Collection, ck Calvin Klein and Calvin Klein Jeans for fall 2010. It marks the first time in years the fashion house has chosen to use one model for three of its brands, and Stone will be exclusive to CKI for all apparel advertising and runway appearances for fall. Ending the year she won British Fashion Awards's Model of the year 2010, hoping it would finally give her some public recognition.
Stone is featured in the 2011 Pirelli Calendar photographed by Karl Lagerfeld. Stone is part of history, in what marks Vogue UK's first multi-cover in the publication's 95-years, landing one of the three May 2011 covers in celebration of the Wedding of Prince William of Wales and Kate Middleton. She debut on Forbes' World's Top-Earning Models list ranking No. 7, with estimated earnings of $4.5 million since May of last year (2010–2011).
Stone is again featured in the 2012 Pirelli Calendar photographed by Mario Sorrenti and also as the face of Calvin Klein's 2012 Underwear campaign.
Stone was ranked #1 on models.com's "Top 50 Models" list from Spring 2010 to Summer 2012 before moving to their "Industry Icons" list and she was also ranked the 9th sexiest model on their Top Sexiest Models list.