Knocking out the activity of a gene provides information about what that gene normally does. Humans share many genes with mice. Consequently, observing the characteristics of knockout mice gives researchers information that can be used to better understand how a similar gene may cause or contribute to disease in humans.
Examples of research in which knockout mice have been useful include studying and modeling different kinds of cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging and Parkinson's disease. Knockout mice also offer a biological and scientific context in which drugs and other therapies can be developed and tested.
Millions of knockout mice are used in experiments each year.
Read more about this topic: Knockout Mouse
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Famous quotes containing the word use:
“... it is use, and use alone, which leads one of us, tolerably trained to recognize any criterion of grace or any sense of the fitness of things, to tolerate ... the styles of dress to which we are more or less conforming every day of our lives. Fifty years hence they will seem to us as uncultivated as the nose-rings of the Hottentot seem today.”
—Elizabeth Stuart Phelps (18441911)