Keratocystic Odontogenic Tumour - Malignant Transformation

Malignant Transformation

Malignant transformation to squamous cell carcinoma may occur, but is unusual.

Read more about this topic:  Keratocystic Odontogenic Tumour

Other articles related to "malignant transformation":

Non-drug Treatments For Neurofibroma - Plexiform Neurofibroma - Surgical Treatment of Plexiform Neurofibroma
... are sometimes removed due to the possibility of malignant transformation ... involved causing pain and numbness in the leg, and because there was a possibility for malignant transformation, as growth in the mass was realized by the family members of the patient.” In layman’s terms, they ...
Malignant Transformation

Malignant transformation is the process by which cells acquire the properties of cancer. This may occur as a primary process in normal tissue, or secondarily as malignant degeneration of a previously existing benign tumor.

There are many causes of primary malignant transformation, or tumorigenesis. The underlying commonality is genetic mutation either by inheritance or more commonly by acquiring mutations in one's DNA over time. Although malignant transformation may occur because of changes within the cell, it can be induced by inorganic toxic substances such as cadmium or arsenite and organics such as tobacco-specific nitrosamines. It is also thought that some malignant transformations are due to viruses such as the Epstein-Barr virus, although this is currently restricted to just a few cancer types. A more common cancer associated with viral infection is cervical cancer, which has been linked to the human papilloma virus.

Malignant transformation of cells in a benign tumor may be detected by pathologic examination of tissues. Often the clinical signs and symptoms are suggestive of a malignant tumor. The physician, during the medical history examination, can find that there have been changes in size or patient sensation and, upon direct examination, that there has been a change in the lesion itself.

Risk assessments can be done and are known for certain types of benign tumor which are known to undergo malignant transformation. One of the better known examples of this phenomenon is the progression of a nevus to melanoma.

Lichen Planus - Signs and Symptoms
... This form may undergo malignant transformation, although this is controversial ... The malignant transformation rate is thought to be less than 1%, however it has been reported to be as high as 5% ... is recommended to rule out precancerous (premalignant) change or malignant transformation ...

Famous quotes containing the word malignant:

    Our civilization survives in the complacency of cowardly or malignant minds—a sacrifice to the vanity of ageing adolescents.... In 1953, excess is always a comfort, and sometimes a career.
    Albert Camus (1913–1960)