Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to differentiate into a monocyte precursor cell.

Read more about IRF8:  Function, Knockout Studies, Clinical Significance

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IRF8 - Clinical Significance
... In myeloid cells, IRF8 regulates the expression of Bax and Fas to regulate apoptosis ... In chronic myelogenous leukemia (CML), IRF8 regulates acid ceramidase to mediiate CML apoptosis ... IRF8 is highly expressed in myeloid cells and was originally identified in as a critical linage-specific transcription factor for myeloid cell differentiation ...