Interleukin-12 Subunit Beta

Interleukin-12 Subunit Beta

Identifiers Symbols IL12B; CLMF; CLMF2; IL-12B; NKSF; NKSF2 External IDs OMIM: 161561 MGI: 96540 HomoloGene: 1648 GeneCards: IL12B Gene

Gene Ontology
Molecular function cytokine receptor activity
cytokine activity
interleukin-12 receptor binding
protein binding
growth factor activity
interleukin-12 alpha subunit binding
identical protein binding
protein homodimerization activity
interleukin-23 receptor binding
protein heterodimerization activity
Cellular component extracellular space
cytoplasm
membrane
interleukin-12 complex
interleukin-23 complex
Biological process positive regulation of T cell mediated cytotoxicity
positive regulation of defense response to virus by host
positive regulation of T-helper 1 type immune response
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
negative regulation of inflammatory response to antigenic stimulus
cell cycle arrest
response to UV-B
positive regulation of activation of JAK2 kinase activity
cell migration
sexual reproduction
natural killer cell activation
negative regulation of interleukin-10 production
negative regulation of interleukin-17 production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-17 production
positive regulation of tumor necrosis factor production
positive regulation of natural killer cell activation
positive regulation of natural killer cell proliferation
positive regulation of tissue remodeling
positive regulation of smooth muscle cell apoptotic process
regulation of cytokine biosynthetic process
T-helper 1 type immune response
T-helper cell differentiation
interferon-gamma biosynthetic process
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of NF-kappaB import into nucleus
regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat4 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
defense response to protozoan
positive regulation of memory T cell differentiation
negative regulation of growth of symbiont in host
positive regulation of interferon-gamma biosynthetic process
positive regulation of osteoclast differentiation
positive regulation of cell adhesion
negative regulation of smooth muscle cell proliferation
positive regulation of lymphocyte proliferation
positive regulation of inflammatory response
defense response to Gram-negative bacterium
positive regulation of NK T cell activation
positive regulation of NK T cell proliferation
defense response to virus
cellular response to lipopolysaccharide
cellular response to interferon-gamma
positive regulation of T-helper 17 type immune response
positive regulation of T-helper 17 cell lineage commitment
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3593 16160 Ensembl ENSG00000113302 ENSMUSG00000004296 UniProt P29460 P43432 RefSeq (mRNA) NM_002187 NM_008352 RefSeq (protein) NP_002178 NP_032378 Location (UCSC) Chr 5:
158.74 – 158.76 Mb Chr 11:
44.4 – 44.41 Mb PubMed search

Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (human gene name IL12B) is a subunit of human interleukin 12.

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter gene polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Read more about Interleukin-12 Subunit Beta:  Protein Structure, Protein Function, RNA Editing