Interleukin

Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). The term interleukin derives from (inter-) "as a means of communication", and (-leukin) "deriving from the fact that many of these proteins are produced by leukocytes and act on leukocytes". The name is something of a relic, though (the term was coined by Dr. Vern Paetkau, University of Victoria); it has since been found that interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells.

Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice.

Read more about Interleukin:  List of Human Interleukins

Other articles related to "interleukin, interleukins":

Lymphokine
... Important lymphokines secreted by the T helper cell include Interleukin 2 Interleukin 3 Interleukin 4 Interleukin 5 Interleukin 6 Granulocyte-macrophage colony-stimulating ...
Cartilage Glycoprotein 39
... kinase B signaling cascade • positive regulation of ERK1 and ERK2 cascade • response to interleukin-1 • response to interleukin-6 • cellular response to interleukin-1 • cellular response to tumor ...
Type II Cytokine Receptors - Types - Interleukin Receptors
... Interleukin-10 receptor Interleukin-20 receptor Interleukin-22 receptor Interleukin-28 receptor ...
Canakinumab
... name Ilaris, previously ACZ885) is a human monoclonal antibody targeted at interleukin-1 beta ... It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha ...
List of Human Interleukins
... A list of interleukins Name Source Target receptors Target cells Function IL-1 macrophages, B cells, monocytes, dendritic cells CD121a/IL1R1, CD121b/IL1R2 T helper cells co-stimulation B ...