IL2RA

Identifiers Symbols IL2RA; CD25; IDDM10; IL2R; TCGFR External IDs OMIM: 147730 MGI: 96549 HomoloGene: 360 ChEMBL: 1778 GeneCards: IL2RA Gene

Gene Ontology
Molecular function interleukin-2 receptor activity
drug binding
interleukin-2 binding
Cellular component plasma membrane
external side of plasma membrane
integral to membrane
Biological process inflammatory response to antigenic stimulus
apoptotic process
activation-induced cell death of T cells
immune response
cell surface receptor signaling pathway
Notch signaling pathway
cell proliferation
positive regulation of activated T cell proliferation
negative regulation of T cell proliferation
positive regulation of apoptotic process
positive regulation of T cell differentiation
regulation of T cell homeostatic proliferation
negative regulation of defense response to virus
negative regulation of inflammatory response
negative regulation of immune response
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3559 16184 Ensembl ENSG00000134460 ENSMUSG00000026770 UniProt P01589 P01590 RefSeq (mRNA) NM_000417 NM_008367 RefSeq (protein) NP_000408 NP_032393 Location (UCSC) Chr 10:
6.05 – 6.1 Mb Chr 2:
11.64 – 11.69 Mb PubMed search

Interleukin-2 receptor alpha chain is a protein that in humans is encoded by the IL2RA gene.

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is currently unknown.

Infection by the protozoan Trypanosoma cruzi causes Chagas disease, characterized by a reduction in the amount of IL2RA expressed on the surface of immune cells. This leads to chronic immune suppression, becoming increasingly severe over the course of many years and ultimately resulting in death if left untreated.