Hopsewee Plantation, also known as Thomas Lynch, Jr., Birthplace or Hopsewee-on-the-Santee, is a house built in 1735 near Georgetown, South Carolina. It was the birthplace of Thomas Lynch, Jr., a signer of the Declaration of Independence, and served as a Lowcountry rice plantation. The Lynch family sold the house in 1752 to Robert Hume whose son, John Hume, lived at Hopsewee in the winter after inheriting it. Upon his death in 1841, his own son, John Hume Lucas, inherited the house. John Hume Lucas died in 1853. Like many Santee plantations, it was abandoned during the Civil War. After the war, rice was never planted again, but the Lucas family continued to occupy Hopsewee until 1925. In September 1949, Col. and Mrs. Wilkinson bought the house and occupied it.

According to the National Park Service, "the frame building, a fine example of a Carolina "low country" plantation house, shows West Indian influence, with its double-tiered piazza and dormered hip roof." The house is made of black cypress and rests on a brick foundation which forms a cellar. The house is forty feet wide and fifty feet deep. Each floor has four rooms with a central hall. The piazzas were added in 1845 and replace an earlier verandah.

It was declared a National Historic Landmark in 1971.

It is located about 13 miles south of Georgetown on U.S. Highway 17, in the vicinity of North Santee on the North Santee River.

The house continues to be a private residence, but is open to the public for tours. It is furnished with 18th and 19th century period furniture.