Hepcidin

Hepcidin is a peptide hormone produced by the liver. It was discovered in 2000, and appears to be the master regulator of iron homeostasis in humans and other mammals. Hepcidin functions to regulate iron transport across the gut mucosa, thereby preventing excess iron absorption and maintaining normal iron levels within the body. In humans, HAMP is the gene that encodes for hepcidin.

Read more about Hepcidin:  Structure, Function, History, Clinical Significance

Other articles related to "hepcidin":

Iron Metabolism Disorder
... Hepcidin is the master regulator of iron metabolism and, therefore, most genetic forms of iron overload can be thought of as relative hepcidin deficiency in one way or another ... overload, juvenile hemochromatosis, is a result of severe hepcidin deficiency ... mutations in the gene for ferroportin, prove the rule these people have plenty of hepcidin, but their cells lack the proper response to it ...
Ferroportin - Clinical Significance
... Ferroportin and hepcidin are critical proteins for the regulation of systemic iron homeostasis ... Both ferroportin and hepcidin are expressed in cultured human breast epithelial cells and hepcidin regulates ferroportin in these cells ...
Hemojuvelin - Clinical Significance
... A small number of patients have mutations in the hepcidin (HAMP) gene ... is that patients have low to undetectable urinary hepcidin levels, suggesting that hemojuvelin is a positive regulator of hepcidin, the central iron regulatory hormone ... As a result, low hepcidin levels would result in increased intestinal iron absorption ...
Hepcidin - Clinical Significance
... overload of iron is associated with low levels of hepcidin ... that patients with β-thalassemia also have low hepcidin levels ... thalassemia than is required for erythropoiesis and whether the concentration of hepcidin is increasing in the body of such patients might be therapeutic, limiting iron ...
Hemojuvelin - Function
... and may signal via the SMAD pathway to regulate hepcidin expression ... Hepcidin levels in the liver are dramatically depressed in these knockout animals ... A soluble form of HJV may be a molecule that suppresses hepcidin expression ...