The hedgehog signaling pathway transmits information to embryonic cells required for proper development. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.
The hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. The pathway takes its name from its polypeptide ligand, an intercellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila. Hh is one of Drosophila's segment polarity gene products, involved in establishing the basis of the fly body plan. The molecule remains important during later stages of embryogenesis and metamorphosis.
Mammals have three hedgehog homologues, DHH, IHH, and SHH which is the best studied. The pathway is equally important during vertebrate embryonic development. In knockout mice lacking components of the pathway, the brain, skeleton, musculature, gastrointestinal tract and lungs fail to develop correctly. Recent studies point to the role of hedgehog signaling in regulating adult stem cells involved in maintenance and regeneration of adult tissues. The pathway has also been implicated in the development of some cancers. Drugs that specifically target hedgehog signaling to fight this disease are being actively developed by a number of pharmaceutical companies.
Other articles related to "signaling, pathways, hedgehog signaling pathway, signaling pathway, hedgehog":
... detect changes in the surrounding environment." For example, ciliary signaling plays a role in the initiation of cellular replacement after cell damage ... addition to this sensory role mediating specific signaling cues, cilia play "a secretory role in which a soluble protein is released to have an effect downstream of the fluid flow" in epithelial cells, and can of ... Signal transduction pathways involved include the Hedgehog signaling pathway and the Wnt signaling pathway ...
... transport • epidermal growth factor receptor signaling pathway • cellular membrane organization • endosomal transport • negative regulation of epidermal growth factor receptor signaling pathway ... related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based ... and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation ...
... The SES evaluated multi-frequency outpulsing signaling as well as voice impairments including sound amplitude, noise, echo, and a variety of other parameters ... Deployment of Common Channel Signaling systems such as Common Channel Interoffice Signaling and later Signaling System #7 obviated the need to monitor multi-frequency signaling as it became obsolete ...
... Hedgehog-like genes, 2 Patched homologs and Patched-related genes exist in the worm C ... The hedgehog-like and Patched-related gene families are very large and function without the need for a Smoothened homolog, suggesting a distinct pattern of selection for cholesterol ... Vertebrates, on the other hand, have several hedgehog ligands that fall within three subgroups - desert, Indian and sonic, each represented by a single ...
Famous quotes containing the word pathway:
“Socrates drinking the hemlock,
And Jesus on the rood;
And millions who, humble and nameless,
The straight, hard pathway plod
Some call it Consecration,
And others call it God.”
—William Herbet Carruth (18591929)