Classes of Growth Factors
Individual growth factor proteins tend to occur as members of larger families of structurally and evolutionarily related proteins. There are many families, which are listed below:
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- Adrenomedullin (AM)
- Angiopoietin (Ang)
- Autocrine motility factor
- Bone morphogenetic proteins (BMPs)
- Brain-derived neurotrophic factor (BDNF)
- Epidermal growth factor (EGF)
- Erythropoietin (EPO)
- Fibroblast growth factor (FGF)
- Glial cell line-derived neurotrophic factor (GDNF)
- Granulocyte colony-stimulating factor (G-CSF)
- Granulocyte macrophage colony-stimulating factor (GM-CSF)
- Growth differentiation factor-9 (GDF9)
- Hepatocyte growth factor (HGF)
- Hepatoma-derived growth factor (HDGF)
- Insulin-like growth factor (IGF)
- Migration-stimulating factor
- Myostatin (GDF-8)
- Nerve growth factor (NGF) and other neurotrophins
- Platelet-derived growth factor (PDGF)
- Thrombopoietin (TPO)
- Transforming growth factor alpha(TGF-α)
- Transforming growth factor beta(TGF-β)
- Vascular endothelial growth factor (VEGF)
- Wnt Signaling Pathway
- placental growth factor (PlGF)
- IL-1- Cofactor for IL-3 and IL-6. Activates T cells.
- IL-2- T-cell growth factor. Stimulates IL-1 synthesis. Activates B-cells and NK cells.
- IL-3- Stimulates production of all non-lymphoid cells.
- IL-4- Growth factor for activated B cells, resting T cells, and mast cells.
- IL-5- Induces differentiation of activated B cells and eosinophils.
- IL-6- Stimulates Ig synthesis. Growth factor for plasma cells.
- IL-7- Growth factor for pre-B cells.
Stimulates cell cycle from G0 phase to G1 phase
Read more about this topic: Growth Factor
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