Glutamate Dehydrogenase 1

Glutamate Dehydrogenase 1

Identifiers Symbols GLUD1; GDH; GDH1; GLUD External IDs OMIM: 138130 MGI: 95753 HomoloGene: 55885 GeneCards: GLUD1 Gene EC number 1.4.1.3

Gene Ontology
Molecular function glutamate dehydrogenase (NAD+) activity
glutamate dehydrogenase
protein binding
ATP binding
GTP binding
identical protein binding
ADP binding
NAD+ binding
leucine binding
Cellular component cytoplasm
mitochondrion
mitochondrial matrix
Biological process glutamate biosynthetic process
glutamate catabolic process
cellular amino acid biosynthetic process
positive regulation of insulin secretion
cellular nitrogen compound metabolic process
small molecule metabolic process
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2746 14661 Ensembl ENSG00000148672 ENSMUSG00000021794 UniProt P00367 P26443 RefSeq (mRNA) NM_005271.3 NM_008133.4 RefSeq (protein) NP_005262.1 NP_032159.1 Location (UCSC) Chr 10:
88.81 – 88.85 Mb Chr 14:
34.31 – 34.35 Mb PubMed search

GLUD1 (Glutamate dehydrogenase 1) is a mitochondrial matrix enzyme, with a key role in the nitrogen and glutamate (Glu) metabolism and the energy homeostasis. GLUD1 is expressed at high levels in liver, brain, pancreas and kidney, but not in muscle. In the pancreatic cells, GLUD1 is thought to be involved in insulin secretion mechanisms. In nervous tissue, where Glu is present in concentrations higher than in the other tissues, GLUD1 appears to function in both the synthesis and the catabolism of Glu and perhaps in ammonia detoxification.

Read more about Glutamate Dehydrogenase 1:  Structure, Function, Regulation, Gene

Other articles related to "glutamate dehydrogenase 1":

Glutamate Dehydrogenase 1 - Gene
... There is evidence that GLUD1 has been retro-posed to the X chromosome, where it gave rise to the intronless GLUD2 through random mutations and natural selection ... GLUD2 have adapted to the particular needs of the nervous system where it is specifically expressed ...