Glucose 6-phosphatase

Glucose 6-phosphatase (G6Pase) is an enzyme that hydrolyzes glucose-6-phosphate resulting in the creation of a phosphate group and free glucose. Glucose is then exported from the cell via glucose transporter membrane proteins. This catalysis completes the final step in gluconeogenesis and glycogenolysis and therefore plays a key role in the homeostatic regulation of blood glucose levels. In humans, there are three isozymes, G6PC, G6PC2, and G6PC3.

The G6Pase family includes two functional phosphohydrolases; G6Pase-α and G6Pase-β, the former of which is the prototype. G6Pase-α and G6Pase-β share similar active site structure, topology, mechanism of action, and kinetic properties with respect to G6P hydrolysis.

Read more about Glucose 6-phosphatase:  Structure and Function, Mechanism, Expression, Clinical Significance

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Glucose 6-phosphatase - Clinical Significance
... Mutations of the Glucose-6-phosphatase system specifically the Glucose-6-phosphatase-α subunit (G6Pase- α), Glucose-6-transporter (G6PT), and ... mutations lead to the prevalence of GSD-1 by preventing the transport of Glucose-6-phosphate (G6P) into the luminal portion of the ER and also inhibiting the conversion of G6P into glucose to be ... The third type of Glucose-6-phosphatase deficiency, G6Pase- β deficiency, is characterized by a congenital neutropenia syndrome in which neutrophils exhibit enhanced ...