Glioblastoma Multiforme

Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans, involving glial cells and accounting for 52% of all functional tissue brain tumor cases and 20% of all intracranial tumors. Despite being the most prevalent form of primary brain tumor, GBM incidence is only 2–3 cases per 100,000 people in Europe and North America. According to the WHO classification of the tumors of the central nervous system, the standard name for this brain tumor is "glioblastoma"; it presents two variants: giant cell glioblastoma and gliosarcoma.

Treatment can involve chemotherapy, radiation, radiosurgery, corticosteroids, antiangiogenic therapy, surgery and experimental approaches such as gene transfer.

With the exception of the brainstem gliomas, glioblastoma has the worst prognosis of any central nervous system (CNS) malignancy, despite multimodality treatment consisting of open craniotomy with surgical resection of as much of the tumor as possible, followed by concurrent or sequential chemoradiotherapy, antiangiogenic therapy with bevacizumab, gamma knife radiosurgery, and symptomatic management with corticosteroids. Prognosis is very poor, with a median survival time of approximately 12-14 months and is almost invariably fatal.

Read more about Glioblastoma Multiforme:  Signs and Symptoms, Causes, Pathogenesis, Diagnosis, Treatment, Prognosis

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... A DNA test can be conducted on glioblastomas to determine whether or not the promoter of the MGMT gene is methylated ... However, much remains unknown about why some patients survive longer with glioblastoma ... Age of under 50 is linked to longer survival in glioblastoma multiforme, as is 98%+ resection and use of temozolomide chemotherapy and better Karnofsky performance scores ...
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... States Republican National Committee Glioblastoma multiforme 1 year William J ... Ted Kennedy 1932–2009 United States Senator Glioblastoma multiforme 15 months Peter Law 1948–2006 Welsh politician, independent Member of Parliament (MP) and AM. 1941–2005 Political activist and former president of the Communist Party of Chile Glioblastoma multiforme — Robert Evander McNair 1923–2007 Governor of South Carolina — 50 days Lennart Meri 1929 ...
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