Ghrelin - Synthesis and Variants

Synthesis and Variants

The mRNA from the ghrl gene codes for a 117 amino acid peptide called preproghrelin, containing 4 exons of the GHRL gene. The signalling peptide molecule of this larger precursor is cleaved to produce proghrelin. Proghrelin is cleaved in two to produce the 28 amino acid peptide ghrelin (unacylated) and C-ghrelin (of which obestatin is presumed to be a cleaved form).

'Ghrelin' usually refers to the octanoylated form of ghrelin (acyl ghrelin). This is the 28 amino acid peptide sequence with an octanoylation on the third amino acid (Serine). The octanoylation is performed by the Ghrelin O-acyltransferase (GOAT) protein (a member of the membrane-bound O-Acyltransferase family of proteins), located in the stomach and pancreas. This peptide can activate the GHSR receptor and is thus known as the active form of ghrelin. The non-octanoylated form is known as desacyl ghrelin or the inactive form (it does not activate GHSR1a and thus does not release GH like acyl ghrelin), however studies have shown it has its own effects. Side chains other than octanoyl have also been observed.

Read more about this topic:  Ghrelin

Other articles related to "synthesis":

N-Formylmethionine
... is specifically used for initiation of protein synthesis from bacterial and organellar genes, and may be removed post-translationally ... fMet plays a crucial part in the protein synthesis of bacteria, mitochondria and chloroplasts ... It is not used in cytosolic protein synthesis of eukaryotes, where eukaryotic nuclear genes are translated ...
Hemetsberger Indole Synthesis
... The Hemetsberger indole synthesis (also called the Hemetsberger-Knittel synthesis) is a chemical reaction that thermally decomposes a 3-aryl-2-azido-propenoic ester into an indole-2-carboxylic ester ...
Organotellurium Chemistry - Applications - Organic Synthesis
... Diphenyl ditelluride is used as a source of PhTe- in organic synthesis ... in transmetallation is used in the synthesis of lithium reagents with demanding functional groups ... Olefin synthesis Like the selenium counterpart selenoxide elimination, certain telluroxides (RTeOR) can form alkenes on heating ...
Synthesis - Clothing
... Synthesis (clothing), a garment or outfit worn in ancient Rome for dining or special occasions ...

Famous quotes containing the words variants and/or synthesis:

    Nationalist pride, like other variants of pride, can be a substitute for self-respect.
    Eric Hoffer (1902–1983)

    The new shopping malls make possible the synthesis of all consumer activities, not least of which are shopping, flirting with objects, idle wandering, and all the permutations of these.
    Jean Baudrillard (b. 1929)