|Molecular function||• RNA polymerase II core promoter proximal region sequence-specific DNA binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
• DNA binding
• sequence-specific DNA binding transcription factor activity
• transcription coactivator activity
• protein binding
• transcription regulatory region DNA binding
• protein heterodimerization activity
|Cellular component||• nuclear chromatin
|Biological process||• negative regulation of transcription from RNA polymerase II promoter
• in utero embryonic development
• transcription from RNA polymerase II promoter
• positive regulation of transcription from RNA polymerase II promoter
|Sources: Amigo / QuickGO|
27.11 – 27.14 Mb
84.83 – 84.86 Mb
GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene.
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype.
Read more about GABPA: Interactions
Other articles related to "gabpa":
... GABPA has been shown to interact with Host cell factor C1, Sp1 transcription factor and Sp3 transcription factor ...