GABPA

GABPA

Identifiers Symbols GABPA; E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A; RCH04A07 External IDs OMIM: 600609 MGI: 95610 HomoloGene: 1543 GeneCards: GABPA Gene

Gene Ontology
Molecular function RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
DNA binding
sequence-specific DNA binding transcription factor activity
transcription coactivator activity
protein binding
transcription regulatory region DNA binding
protein heterodimerization activity
Cellular component nuclear chromatin
nucleus
nucleolus
Biological process negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2551 14390 Ensembl ENSG00000154727 ENSMUSG00000008976 UniProt Q06546 Q00422 RefSeq (mRNA) NM_001197297 NM_008065 RefSeq (protein) NP_001184226 NP_032091 Location (UCSC) Chr 21:
27.11 – 27.14 Mb Chr 16:
84.83 – 84.86 Mb PubMed search

GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene.

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype.

Read more about GABPA:  Interactions

Other articles related to "gabpa":

GABPA - Interactions
... GABPA has been shown to interact with Host cell factor C1, Sp1 transcription factor and Sp3 transcription factor ...