Alcohol intoxication has been shown to be directly connected to the actions of GIRK channels. GIRK channels have a hydrophobic pocket that is capable of binding ethanol, the type of alcohol found in alcoholic beverages. When ethanol acts as an agonist, GIRK channels in the brain experience prolonged opening. This causes decreased neuronal activity, the result of which manifests as the symptoms of alcohol intoxication. The discovery of the hydrophobic pocket capable of binding ethanol is significant in the field of clinical pharmacology. Agents that can act as agonists to this binding site can be potentially useful in the creation of drugs for the treatment of neurological disorders such as epilepsy in which neuronal firing exceeds normal levels.
Other articles related to "alcohol intoxication, alcohol, intoxication":
... Some religious groups permit the consumption of alcohol ... Some permit consumption but prohibit intoxication, while others prohibit alcohol consumption altogether ... is a prohibition on the consumption of grape-based alcoholic beverages, and intoxication is considered as an abomination in the Hadith ...
... Y90) Evidence of alcohol involvement determined by blood alcohol level (Y90.0) Blood alcohol level of less than 20 mg/100 ml (Y90.1) Blood alcohol level of 20–39 mg/100 ml (Y90.2) Blood ...
... Alcohol intoxication (also known as drunkenness or inebriation) is a physiological state induced by the consumption of alcohol ... Intoxication is the consequence of alcohol entering the bloodstream faster than it can be metabolized by the liver ... Some effects of alcohol intoxication are central to alcohol's desirability as a beverage and its history as the world's most widespread recreational drug ...
Famous quotes containing the words intoxication and/or alcohol:
“We are living now, not in the delicious intoxication induced by the early successes of science, but in a rather grisly morning-after, when it has become apparent that what triumphant science has done hitherto is to improve the means for achieving unimproved or actually deteriorated ends.”
—Aldous Huxley (18941963)
“Some parents feel that if they introduce their children to alcohol gradually in the home environment, the children will learn to use alcohol in moderation. Im not sure thats such a good idea. First of all, alcohol is not healthy for the growing child. Second, introducing alcohol to a child suggests that you condone drinkingeven to the point where you want to teach your child how to drink.”
—Lawrence Balter (20th century)