Fumarate Reductase

Fumarate reductase is the enzyme that converts fumarate to succinate, and is important in microbial metabolism as a part of anaerobic respiration.

Succinate + acceptor <=> fumarate + reduced acceptor

In other words, fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalysed by the related complex II of the respiratory chain (succinate dehydrogenase).

Fumarate reductase complex includes three subunits. Subunit A contains the site of fumarate reduction and a covalently bound flavin adenine dinucleotide prosthetic group. Subunit B contains three iron-sulphur centres. The menaquinol-oxidizing subunit C consists of five membrane-spanning, primarily helical segments and binds two haem b molecules. The D subunit may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane.

Other articles related to "fumarate reductase":

Oxantel
... his Associate Professor Stuart Dashper are currently testing its ability as a Fumarate reductase inhibitor ... Fumarate reductase is an enzyme that has been found in the pathogenic bacteria in the biofilm in periodontal pockets ... As such, the role of the Oxantel as a fumarate reductase inhibitor would be to kill the bacteria responsible for periodontal disease ...