Fatty Acid Synthase
|Molecular function||• nucleotide binding
• fatty acid synthase activity
• protein binding
• zinc ion binding
|Cellular component||• cytoplasm
• Golgi apparatus
• plasma membrane
• glycogen granule
|Biological process||• energy reserve metabolic process
• fatty acid metabolic process
• fatty acid biosynthetic process
• vitamin metabolic process
• water-soluble vitamin metabolic process
• pantothenate metabolic process
• triglyceride biosynthetic process
• positive regulation of cellular metabolic process
• long-chain fatty-acyl-CoA biosynthetic process
• cellular lipid metabolic process
• small molecule metabolic process
|Sources: Amigo / QuickGO|
80.04 – 80.06 Mb
120.81 – 120.82 Mb
Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene.
Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one functional domain to the next.
Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.
Other articles related to "acids, fatty acid synthase, fatty, synthase, fatty acid, acid, fatty acids":
... tuberculosis produces three main types of mycolic acids alpha-, methoxy-, and keto- ... Alpha-mycolic acids comprise at least 70% of the mycolic acids present in the organism and contain several cyclopropane rings ... Methoxy-mycolic acids, which contain several methoxy groups, comprise between 10% and 15% of the mycolic acids in the organism ...
... In some cancer cell lines, this protein has been found to be fused with estrogen receptor alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha ... An association with uterine leiomyomata has been reported. ...
... In enzymology, a fatty-acid synthase (EC 188.8.131.52) is an enzyme that catalyzes the chemical reaction acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ a long-c ... This enzyme is also called yeast fatty acid synthase ... This enzyme participates in fatty acid biosynthesis and insulin signaling pathway ...
... This system functions similarly to the branch-chain fatty acid synthesizing system, however it uses short-chain carboxylic acids as primers instead of alpha-keto ... method is used by bacteria that do not have the ability to perform the branch-chain fatty acid system using alpha-keto primers ... In general, the acids needed for these primers are taken up from the environment this is often seen in ruminal bacteria ...
... Much like β-oxidation, straight-chain fatty acid synthesis occurs via the six recurring reactions shown below, until the 16-carbon palmitic acid is produced ... The diagrams presented show how fatty acids are synthesized in microorganisms and list the enzymes found in Escherichia coli ... These reactions are performed by fatty acid synthase II (FASII), which in general contain multiple enzymes that act as one complex ...