Fatty Acid Synthase

Fatty Acid Synthase

Identifiers Symbols FASN; FAS; OA-519; SDR27X1 External IDs OMIM: 600212 MGI: 95485 HomoloGene: 55800 ChEMBL: 4158 GeneCards: FASN Gene EC number 1.1.1.100

Gene Ontology
Molecular function nucleotide binding
fatty acid synthase activity


3-oxoacyl-
3-oxoacyl-
3-hydroxypalmitoyl-
enoyl-
oleoyl-
protein binding
zinc ion binding
myristoyl-
palmitoyl-
3-hydroxyoctanoyl-
Cellular component cytoplasm
mitochondrion
Golgi apparatus
cytosol
plasma membrane
melanosome
glycogen granule
Biological process energy reserve metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
vitamin metabolic process
water-soluble vitamin metabolic process
pantothenate metabolic process
triglyceride biosynthetic process
positive regulation of cellular metabolic process
long-chain fatty-acyl-CoA biosynthetic process
cellular lipid metabolic process
small molecule metabolic process
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2194 14104 Ensembl ENSG00000169710 ENSMUSG00000025153 UniProt P49327 P19096 RefSeq (mRNA) NM_004104.4 NM_007988.3 RefSeq (protein) NP_004095.4 NP_032014.3 Location (UCSC) Chr 17:
80.04 – 80.06 Mb Chr 11:
120.81 – 120.82 Mb PubMed search


Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene.

Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one functional domain to the next.

Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.

Read more about Fatty Acid SynthaseMetabolic Function, Classes, Structure, Regulation, Clinical Significance

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