Enzyme-linked Receptor

An enzyme-linked receptor also known as a catalytic receptor is a transmembrane receptor, where the binding of an extracellular ligand causes enzymatic activity on the intracellular side. Hence a catalytic receptor is an integral membrane protein possessing both enzymatic catalytic and receptor functions.

They have two important domains, an extra-cellular ligand binding domain and an intracellular domain, which has a Catalytic function; and a transmembrane helix. The signaling molecule binds to the receptor outside of the cell and causes a conformational change on the Catalytic function located on the receptor inside of the cell.

Examples of the enzymatic activity include:

  • Receptor tyrosine kinase, as in fibroblast growth factor receptor. Most enzyme-linked receptors are of this type.
  • Serine/threonine-specific protein kinase, as in bone morphogenetic protein
  • Guanylate cyclase, as in atrial natriuretic factor receptor

Read more about Enzyme-linked Receptor:  Types

Other articles related to "receptors, receptor":

Enzyme-linked Receptor - Types
... The following is a list of the five major families of catalytic receptors Family Member Gene Catalytic activity Endogenous Ligands Synthetic Ligands Erb ErbB1 (epidermal growth factor receptor ...

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