EGR1

EGR1

Identifiers Symbols EGR1; AT225; G0S30; KROX-24; NGFI-A; TIS8; ZIF-268; ZNF225 External IDs OMIM: 128990 MGI: 95295 HomoloGene: 56394 GeneCards: EGR1 Gene

Gene Ontology
Molecular function transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
DNA binding
double-stranded DNA binding
sequence-specific DNA binding transcription factor activity
protein binding
zinc ion binding
histone acetyltransferase binding
sequence-specific DNA binding
Cellular component nucleus
nucleoplasm
cytoplasm
Biological process negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
learning or memory
response to glucose stimulus
cytokine-mediated signaling pathway
T cell differentiation
BMP signaling pathway
response to insulin stimulus
regulation of protein sumoylation
positive regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
regulation of long-term neuronal synaptic plasticity
type I interferon-mediated signaling pathway
interleukin-1-mediated signaling pathway
cellular response to gamma radiation
cellular response to heparin
cellular response to mycophenolic acid
glomerular mesangial cell proliferation
positive regulation of glomerular metanephric mesangial cell proliferation
negative regulation of canonical Wnt receptor signaling pathway
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1958 13653 Ensembl ENSG00000120738 ENSMUSG00000038418 UniProt P18146 P08046 RefSeq (mRNA) NM_001964.2 NM_007913.5 RefSeq (protein) NP_001955.1 NP_031939.1 Location (UCSC) Chr 5:
137.8 – 137.81 Mb Chr 18:
34.86 – 34.86 Mb PubMed search

EGR-1 (Early growth response protein 1) also known as Zif268 (zinc finger protein 225) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene.

EGR-1 is a mammalian transcription factor. It was also named Krox-24, TIS8, and ZENK. It was originally discovered in mice.

Read more about EGR1:  Function, Structure, DNA Binding Specificity, Interactions