DXP Reductoisomerase

DXP reductoisomerase or (1-deoxy-d-xylulose 5-phosphate reductoisomerase) is an enzyme that intraconverts 1-deoxy-D-xylulose 5-phosphate and 2-C-methyl-D-erythritol 4-phosphate.

  • 1-Deoxy-D-xylulose 5-phosphate

  • 2-C-methylerythritol 4-phosphate

It is classified under EC 1.1.1.267.

It is part of the non-mevalonate pathway, and it is inhibited by fosmidomycin.

It is normally abbreviated DXR, but it is sometimes named IspC.

This enzyme is responsible for terpenoid biosynthesis in some organisms. In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate reductoisomerase is the first committed enzyme of the non-mevalonate pathway for isoprenoid biosynthesis. The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with Mn2+ being most effective.