A drug-eluting stent (DES) is a peripheral or coronary stent (a scaffold) placed into narrowed, diseased peripheral or coronary arteries that slowly releases a drug to block cell proliferation. This prevents fibrosis that, together with clots (thrombus), could otherwise block the stented artery, a process called restenosis. The stent is usually placed within the peripheral or coronary artery by an Interventional cardiologist or Interventional Radiologist during an angioplasty procedure.
Drug-eluting stents in current clinical use were approved by the FDA after clinical trials showed they were statistically superior to bare-metal stents (BMS) for the treatment of native coronary artery narrowings, having lower rates of major adverse cardiac events (MACE) (usually defined as a composite clinical endpoint of death + myocardial infarction + repeat intervention because of restenosis).
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... and paclitaxel, this sirolimus analogue designed for use in stents with phosphorylcholine as a carrier ... Their ZoMaxx stent is a zotarolimus-eluting, stainless steel and tantalum–based stent a modified phosphorylcholine slowly releases the zotarolimus ... Medtronic which is researching the effectiveness in a drug-eluting stent of their own ...