DNA Repair and Recombination Protein RAD54-like

DNA repair and recombination protein RAD54-like is a protein that in humans is encoded by the RAD54L gene.

The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA pairing, and stimulate DNA recombination.

Read more about DNA Repair And Recombination Protein RAD54-like:  Introduction To RAD54, Human RAD54 (hRAD54), Actions of HRAD54, Inactivation of HRAD54 and Cancer Susceptibility

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DNA Repair And Recombination Protein RAD54-like - Inactivation of HRAD54 and Cancer Susceptibility
... Normally, RAD51 interacts with both BRCA1 and BRCA2 protein products to cause tumor suppression ... RAD54’s involvement as a necessary recombinational protein is supported in the finding that there are mutations of RAD54 in a small percentage of studied breast and colon carcinomas, as ...

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